{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:48Z","timestamp":1772160888917,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      More than 11 million people were estimated to have been infected by\n                      <jats:italic>Schistosoma japonicum<\/jats:italic>\n                      in China before the 1950s. However, few studies have been conducted to evaluate the longitudinal effects of previous schistosome infection (PSI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to evaluate the association of PSI with fatty liver and coronary heart disease in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional study was conducted in regions which were all reportedly heavily endemic for\n                      <jats:italic>S japonicum<\/jats:italic>\n                      in China. All data were collected using a questionnaire administered and health examinations by well\u2010trained medical professionals. 2867 participants aged 40\u00a0years and older were enrolled. Among these, 731 patients with PSI were selected as study subjects and 2136 subjects served as controls. Comparisons between groups were performed with or without an adjustment for a covariate, using Student's\n                      <jats:italic>t<\/jats:italic>\n                      tests for continuous variables and chi\u2010square testing for categorical variables. Multivariable logistic models were used to estimate the associations between PSI and fatty liver or coronary heart disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The PSI participants had significantly lower levels of triglyceride, low\u2010density lipoprotein cholesterol, fasting blood glucose, uric acid, serum creatinine, urea nitrogen, platelet, total protein and globulin as well as a lower prevalence of fatty liver (13.3% vs 53.6%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and coronary heart disease (3.4% vs 6.0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) compared with the uninfected, contemporaneous controls (without PSI), whereas the PSI participants had higher levels of high\u2010density lipoprotein cholesterol, direct bilirubin and a higher prevalence of hepatic dysfunction compared with those without PSI (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found PSI significantly negatively associated with fatty liver and coronary heart disease. However, further studies on schistosomiasis may provide new directions for prevention and treatment of fatty liver and coronary heart disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pim.12822","type":"journal-article","created":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T06:24:17Z","timestamp":1610864657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of previous schistosome infection with fatty liver and coronary heart disease: A cross\u2010sectional study in china"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-6964","authenticated-orcid":false,"given":"Zhuo\u2010qun","family":"Zou","sequence":"first","affiliation":[{"name":"Gerontology Department Huadong Sanatorium Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-8717","authenticated-orcid":false,"given":"Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Gerontology Department Huadong Sanatorium Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6701-6929","authenticated-orcid":false,"given":"Huai\u2010qin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Gerontology Department Huadong Sanatorium Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-0873","authenticated-orcid":false,"given":"Guo\u2010yue","family":"Guan","sequence":"additional","affiliation":[{"name":"Gerontology Department Huadong Sanatorium Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0358-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054855"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834bbba8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004140"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323910"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.1903"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64617"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1201475"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838871"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/795210"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0800135"},{"issue":"3","key":"e_1_2_9_13_1","first-page":"235","article-title":"Understanding of hepatic fibrosis and advanced schistosomiasis in the past and future","volume":"20","author":"Cai WM","year":"2008","journal-title":"Chinese J Schistosomiasis Control"},{"key":"e_1_2_9_14_1","unstructured":"Chinese Center for Disease Control and Prevention.http:\/\/www.ipd.org.cn"},{"key":"e_1_2_9_15_1","volume-title":"Schistosomiasis Research Data Compilation","year":"1980"},{"key":"e_1_2_9_16_1","volume-title":"Report of a WHO consultation. 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A practical guide to the standardized use of ultrasonography for the assessment of schistosomiasis\u2010related morbidity, 2000, Report of a WHO expert committee","author":"WHO Report","year":"2000"},{"issue":"3","key":"e_1_2_9_18_1","first-page":"163","article-title":"Guidelines for the Diagnosis and Treatment of Non\u2010alcoholic Fatty Liver Disease (2010 Revision)","volume":"18","author":"Chinese Society of Hepatology, Fatty liver and alcoholic liver disease group","year":"2010","journal-title":"Chinese J Hepatol"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2015.01.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12187"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.08.128"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2517"},{"issue":"11","key":"e_1_2_9_23_1","first-page":"1525","article-title":"Effects of S japonicum infection on fatty liver and insulin resistance in C57BL\/6J mice","volume":"49","author":"Zhao N","year":"2014","journal-title":"Acta Universitatis Medicinalis Anhui"},{"issue":"4","key":"e_1_2_9_24_1","first-page":"468","article-title":"Effect of S japonicum infection on insulin resistance in mice","volume":"51","author":"Gong AJ","year":"2016","journal-title":"Acta Universitatis Medicinalis Anhui"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.12.007"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2682"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00022.2010"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.09.009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix416"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02353"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pim.12822","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:03:14Z","timestamp":1693551794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,27]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/pim.12822"],"URL":"https:\/\/doi.org\/10.1111\/pim.12822","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PIM.12822\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12822\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12822\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12822\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12822\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12822\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12822\/v2\/review1","asserted-by":"object"}]},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,27]]},"assertion":[{"value":"2020-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12822"}}