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This study aims to evaluate the antitumour effect of <jats:italic>Eimeria stiedae<\/jats:italic> oocyst soluble protein (ESSP). ESSP was extracted, and mice were injected with 5\u00a0\u00d7\u00a010<jats:sup>5<\/jats:sup> CT26 cells in the right axilla, and then, 50\u00a0\u03bcg of ESSP was intraperitoneally injected for 5 continuous days. The effect of ESSP on tumour immunity was detected by flow cytometry 25\u00a0days after the CT26 inoculation. The results showed that ESSP can inhibit the growth of CT26 subcutaneous tumours; significantly increase the expression of MHC I, MHC II, CD80 and CD86 on the surface of splenic dendritic cells; and enhance the level of IL\u201012 secretion. ESSP induced an increase in the number of NK cells in the mouse spleen, and the levels of IFN\u2010\u03b3 and CD107 were upregulated in the NK cells and CD8<jats:sup>+<\/jats:sup> T cells. The number of metastatic nodules in the lung tumours in the mice was significantly reduced, and the number of tubes, area of the loops and total length of the tubes were significantly reduced. ESSP enhances the antitumour immune response and inhibits tumour growth, metastasis and angiogenesis.<\/jats:p>","DOI":"10.1111\/pim.12825","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T01:08:25Z","timestamp":1611882505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antitumour metastasis and the antiangiogenic and antitumour effects of a Eimeria stiedae soluble protein"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8357-432X","authenticated-orcid":false,"given":"Haibin","family":"Huang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Jilin Provincial Engineering Research Center of Animal Probiotics Key Laboratory of animal production and product quality safety of Ministry of Education Jilin Agricultural University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin Provincial Engineering Research Center of Animal Probiotics Key Laboratory of animal production and product quality safety of Ministry of Education Jilin Agricultural University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtao","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin Provincial Engineering Research Center of Animal Probiotics Key Laboratory of animal production and product quality safety of Ministry of Education Jilin Agricultural University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlong","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin Provincial Engineering Research Center of Animal Probiotics Key Laboratory of animal production and product quality safety of Ministry of Education Jilin Agricultural University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin Provincial Engineering Research Center of Animal Probiotics Key Laboratory of animal production and product quality safety of Ministry of Education Jilin Agricultural University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunwei","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin Provincial Engineering Research Center of Animal Probiotics Key Laboratory of animal production and product quality safety of Ministry of Education Jilin Agricultural University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhuan","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin Provincial Engineering Research Center of Animal Probiotics Key Laboratory of animal production and product quality safety of Ministry of Education Jilin Agricultural University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin Provincial Engineering Research Center of Animal Probiotics Key Laboratory of animal production and product quality safety of Ministry of Education Jilin Agricultural University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1195-0920","authenticated-orcid":false,"given":"Chunfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin Provincial Engineering Research Center of Animal Probiotics Key Laboratory of animal production and product quality safety of Ministry of Education Jilin Agricultural University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-1592","authenticated-orcid":false,"given":"Guilian","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Jilin Provincial Engineering Research Center of Animal Probiotics Key Laboratory of animal production and product quality safety of Ministry of Education Jilin Agricultural University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"International Agency for Research on Cancer\u2010World Health Organization. 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