{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:15:22Z","timestamp":1787584522184,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Alveolar echinococcosis (AE) is characterized by a chronically progressing hepatic injury caused by\n                      <jats:italic>Echinococcus multilocularis<\/jats:italic>\n                      . Surgery presently remains the best curative option. Currently, biological predictive features derived from the resected specimens are not suitable to assess surgery efficacy. The present study was designed to investigate whether a selection of markers measured on the resected specimens exhibits predictive features related to parasite viability, or to a total elimination of the parasite, in addition to serological markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>In a collaboration between two centres, one in France (Besan\u00e7on), and one in Switzerland (Bern), samples from 40 AE patients were analysed by microarray and serology techniques, individually. Paired serum samples before and after surgery were obtained for 26 patients. In the sera, a significant decrease in PD\u2010L1 levels was observed after surgery, in addition to anti\u2010Em18 levels. In the liver tissue, low levels of Cluster of Differentiation (CD)\u20103 were correlated with the absence of serum anti\u2010Em18 after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study showed PD\u2010L1 is promising as a potential serological marker and further confirmed the performance of anti\u2010Em18 serology. Further studies on a larger cohort are needed to confirm the utility of performing systematically microarray on resected liver tissue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pim.12827","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T23:00:28Z","timestamp":1614726028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Investigating new serological and tissue markers for the follow\u2010up of patients operated for alveolar echinococcosis"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4144-476X","authenticated-orcid":false,"given":"Anne\u2010Pauline","family":"Bellanger","sequence":"first","affiliation":[{"name":"Parasitology Mycology Department University Hospital Jean Minjoz Besancon France"},{"name":"Chrono\u2010Environment UMR\/CNRS 6249 University of Bourgogne Franche\u2010Comt\u00e9 Besan\u00e7on 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