{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:57:59Z","timestamp":1790506679558,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Programmed death\u20101 (PD\u20101) and programmed death ligand\u20101 (PD\u2010L1) immune checkpoint blockade are efficacious in certain cancer therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The present study aimed to provide a picture about the development of innate and adaptive immune responses upon PD\u2010L1 blockade in treating chronic murine AE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Immune treatment started at 6\u00a0weeks post\u2010\n                      <jats:italic>E.\u00a0multilocularis<\/jats:italic>\n                      infection, and was maintained for 8\u00a0weeks with twice per week anti\u2010PD\u2010L1 administration (intraperitoneal). The study included an outgroup\u2010control with mice perorally medicated with albendazole 5\u00a0d\/wk, and another one with both treatments combined. Assessment of treatment efficacy was based on determining parasite weight, innate and adaptive immune cell profiles, histopathology and liver tissue cytokine levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\/conclusions<\/jats:title>\n                    <jats:p>\n                      Findings showed that the parasite load was significantly reduced in response to PD\u2010L1 blockade, and this blockade (a) contributed to T\u2010cell activity by increasing CD4\n                      <jats:sup>+<\/jats:sup>\n                      \/CD8\n                      <jats:sup>+<\/jats:sup>\n                      effector T cells, and decreasing Tregs; (b) had the capacity to restore DCs and Kupffer cells\/Macrophages; (c) suppressed NKT and NK cells; and thus (d) lead to an improved control of\n                      <jats:italic>E.\u00a0multilocularis<\/jats:italic>\n                      infection in mice. This study suggests that the PD\u2010L1 pathway plays an important role by regulating adaptive and innate immune cells against\n                      <jats:italic>E.\u00a0multilocularis<\/jats:italic>\n                      infection, with significant modulation of tissue inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pim.12834","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T03:37:57Z","timestamp":1616470677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Innate and adaptive immune responses following PD\u2010L1 blockade in treating chronic murine alveolar echinococcosis"],"prefix":"10.1111","volume":"43","author":[{"given":"Fadi","family":"Jebbawi","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital University Hospital of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4144-476X","authenticated-orcid":false,"given":"Anne\u2010Pauline","family":"Bellanger","sequence":"additional","affiliation":[{"name":"Chrono\u2010Environment UMR\/CNRS 6249 University of Bourgogne Franche\u2010Comt\u00e9 Besan\u00e7on France"},{"name":"Parasitology Mycology Department University Hospital Jean Minjoz Besancon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2672-5766","authenticated-orcid":false,"given":"Britta","family":"Lunstr\u00f6m\u2010Stadelmann","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Pathobiology Vetsuisse Faculty Institute of Parasitology University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Rufener","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Pathobiology Vetsuisse Faculty Institute of Parasitology University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Dosch","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital University Hospital of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Goepfert","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Pathobiology Vetsuisse Faculty Institute of Animal Pathology COMPATH University of Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Gottstein","sequence":"additional","affiliation":[{"name":"Institute for Infectious Diseases University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Millon","sequence":"additional","affiliation":[{"name":"Chrono\u2010Environment UMR\/CNRS 6249 University of Bourgogne Franche\u2010Comt\u00e9 Besan\u00e7on France"},{"name":"Parasitology Mycology Department University Hospital Jean Minjoz Besancon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Grandgirard","sequence":"additional","affiliation":[{"name":"Institute for Infectious Diseases University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Leib","sequence":"additional","affiliation":[{"name":"Institute for Infectious Diseases University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Beldi","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital University Hospital of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6110-3711","authenticated-orcid":false,"given":"Junhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Pathobiology Vetsuisse Faculty Institute of Parasitology University of Bern Bern Switzerland"},{"name":"Institute for Infectious Diseases University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2005.11.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1306.061074"},{"key":"e_1_2_9_4_1","first-page":"15","article-title":"Surgical treatment strategies for hepatic alveolar echinococcosis","volume":"1","author":"Salm LA","year":"2019","journal-title":"Food Waterborne Parasitol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1147"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1990.11812496"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00542-18"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015298108"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.04.013"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3239"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/21681805.2013.876550"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2876"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12596"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003755"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12292"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2008.03.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2365"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1059"},{"issue":"1","key":"e_1_2_9_19_1","article-title":"Blocking of PD\u2010L1 on therapeutic dendritic cells modulate in vitro T cells proliferation and differentiation to Th1 and Th17 subpopulations (P4230)","volume":"190","author":"Lopez M","year":"2013","journal-title":"J Immunol"},{"issue":"1","key":"e_1_2_9_20_1","first-page":"1","article-title":"T\u2010cell tolerance and exhaustion in the clearance of Echinococcus multilocularis: role of inoculum size in a quantitative hepatic experimental model","volume":"7","author":"Zhang C","year":"2017","journal-title":"Sci Rep"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30896"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005094"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56336-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.06.003"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.1240"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000431"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1615\/ForumImmunDisTher.2015014188"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-279"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00542-18"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2012.01383.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12467"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00161"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.10.5075"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.55.12.3162-3167.1987"},{"issue":"9","key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.4049\/jimmunol.161.9.4909","article-title":"Proapoptotic activity of a Trypanosoma cruzi ceramide\u2010containing glycolipid turned on in host macrophages by IFN\u2010\u03b3","volume":"161","author":"Freire\u2010de\u2010Lima CG","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0377-4"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135096"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.05.036"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1007-1142b"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01659"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66381"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12291"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02126"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80448-1"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(93)90030-V"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3725"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pim.12834","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T01:20:35Z","timestamp":1693272035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,7]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/pim.12834"],"URL":"https:\/\/doi.org\/10.1111\/pim.12834","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PIM.12834\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12834\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12834\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12834\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PIM.12834\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,7]]},"assertion":[{"value":"2020-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12834"}}