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However, this response damages the host, favouring the parasite survival. In the search for new pharmacological strategies that protect against\n                      <jats:italic>T\u00a0spiralis<\/jats:italic>\n                      infection, a recent study showed that treatment with resiniferatoxin (RTX) modulates the Th1 cytokines production, reducing muscle parasite burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the effect of RTX treatment on the Th2 cytokines production, the number of eosinophils, mast cells and the intestinal expulsion of\n                      <jats:italic>T\u00a0spiralis<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Serum levels of IL\u20104, IL\u201010 and IL\u201013 were quantified by ELISA; the number of eosinophils, mast cells and the adult worms of\n                      <jats:italic>T\u00a0spiralis<\/jats:italic>\n                      in the small intestine was quantified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      RTX treatment increased serum levels of IL\u20104, IL\u201010 and IL\u201013, and it decreases intestinal eosinophilia, however, favours the mastocytosis, promoting\n                      <jats:italic>T\u00a0spiralis<\/jats:italic>\n                      intestinal expulsion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings suggest that RTX is capable to modulate the Th2 immune response, promoting\n                      <jats:italic>T\u00a0spiralis<\/jats:italic>\n                      expulsion, which contributes to the defence against\n                      <jats:italic>T\u00a0spiralis<\/jats:italic>\n                      infection, placing the RTX as a potential immunomodulatory drug.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pim.12840","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T12:08:02Z","timestamp":1619698082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Resiniferatoxin promotes adult worm expulsion in\n                    <i>Trichinella spiralis<\/i>\n                    \u2010infected rats by Th2 immune response modulation"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-1566","authenticated-orcid":false,"given":"Jos\u00e9 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