{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:28:59Z","timestamp":1790731739337,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102017R1D1A3B05035680"],"award-info":[{"award-number":["NRF\u20102017R1D1A3B05035680"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Helminth infection typically induces a Th2 inflammatory response that is characterized by eosinophilia, high levels of IgE and mast cells. LTB4 is generated from innate immune cells, such as neutrophils, macrophages and mast cells, in response to a range of stimuli. It mainly acts on myeloid leukocytes, inducing the activation of integrins, adhesion to endothelium walls, and chemotaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      The objective of the present study was to determine the role of the LTB4 receptor in\n                      <jats:italic>Trichinella spiralis<\/jats:italic>\n                      expulsion. We treated mice with the LTB4 receptor antagonist before infection with\n                      <jats:italic>T.\u00a0spiralis<\/jats:italic>\n                      . We observed that the number of mast cells and worm infection decreased following treatment with the BLT antagonist during the intestinal phase. We also demonstrated that blocking the LTB4 receptor inhibited neutrophil and eosinophil infiltration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Further studies are required to investigate the specific mechanism of mast cell number decrease and worm infection and the in vitro interactions between LTB4 and worm expulsion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pim.12843","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T21:21:39Z","timestamp":1620768099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acceleration of\n                    <i>Trichinella spiralis<\/i>\n                    worm expulsion by leukotriene B4 receptor binding inhibition"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9934-9787","authenticated-orcid":false,"given":"Shin Ae","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Parasitology and Tropical Medicine School of Medicine Pusan National University Yangsan\u2010si Rep. of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6696-7981","authenticated-orcid":false,"given":"Hak Sun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Tropical Medicine School of Medicine Pusan National University Yangsan\u2010si Rep. of Korea"},{"name":"Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan\u2010si Rep. of 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