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The early keratinocyte\u2010derived cytokines and keratinocytes\u2010T cells interactions shape the anti\u2010leishmanial immune responses that contribute to the resistance or susceptibility to leishmaniasis. The keratinocyte\u2010derived cytokines can directly potentiate the leishmanicidal activity of monocytes and macrophages. As keratinocytes express MHC\u2010II and enhance the expression of costimulatory molecules, these cells act as antigen\u2010presenting cells (APCs) in cutaneous leishmaniasis (CL). Depending on the epidermal microenvironment, the keratinocytes induce various types of effector CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Keratinocyte apoptosis and necrosis have been also implicated in ulceration in CL. Further, keratinocytes contribute to the healing of\n                    <jats:italic>Leishmania<\/jats:italic>\n                    \u2010related cutaneous wounds. However, keratinocyte\u2010derived IL\u201010 may play a key role in the development of post\u2010kala\u2010azar dermal leishmaniasis (PKDL). In this\u00a0review, a comprehensive discussion regarding the multiple roles played by\u00a0keratinocytes during leishmaniasis was provided, while highlighting novel insights concerning the immunological and pathological roles of these cells.\n                  <\/jats:p>","DOI":"10.1111\/pim.12870","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T10:43:05Z","timestamp":1621852985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Immunological role of keratinocytes in leishmaniasis"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8180-0602","authenticated-orcid":false,"given":"Abdollah","family":"Jafarzadeh","sequence":"first","affiliation":[{"name":"Department of Immunology School of Medicine Kerman University of Medical Sciences Kerman Iran"},{"name":"Molecular Medicine Research Center Research Institute of Basic Medical Sciences Rafsanjan University of Medical Sciences Rafsanjan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arathi","family":"Nair","sequence":"additional","affiliation":[{"name":"Trident Academy of Creative Technology Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Jafarzadeh","sequence":"additional","affiliation":[{"name":"Student Research Committee School of Medicine Kerman University of Medical Sciences Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Nemati","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine Rafsanjan University of Medical Sciences Rafsanjan Iran"},{"name":"Department of Haematology and Laboratory Sciences School of Para\u2010Medicine Kerman University of Medical Sciences Kerman 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