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In the present study, peripheral blood was collected from 13 patients with advanced schistosomiasis (schistosomiasis group) and 13 uninfected people (control group) to investigate the \u03b3\u03b4 T cells and their subtypes in human schistosomiasis. Compared with the control group, the proportion of V\u03b41 cells and CD27\n                    <jats:sup>+<\/jats:sup>\n                    V\u03b41\n                    <jats:sup>+<\/jats:sup>\n                    cells in the schistosomiasis group increased significantly, while CD27\n                    <jats:sup>\u2212<\/jats:sup>\n                    cells and CD27\n                    <jats:sup>\u2212<\/jats:sup>\n                    V\u03b41\n                    <jats:sup>\u2212<\/jats:sup>\n                    cells decreased. Only the level of IL\u201017A differed between the groups, being significantly decreased in the schistosomiasis group. In the schistosomiasis group, there were no correlations between the liver fibrosis and subsets of \u03b3\u03b4 T cells, or the level of cytokines. Additionally, the level of IL\u201017A correlated positively with the proportion of CD27\n                    <jats:sup>\u2212<\/jats:sup>\n                    V\u03b41\n                    <jats:sup>\u2212<\/jats:sup>\n                    cells. Thus, there was a higher frequency of circulating V\u03b41 \u03b3\u03b4T cells in patients with advanced schistosomiasis. The decreased IL\u201017A might be related to the reduction in CD27\n                    <jats:sup>\u2212<\/jats:sup>\n                    V\u03b41\n                    <jats:sup>\u2212<\/jats:sup>\n                    cell.\n                  <\/jats:p>","DOI":"10.1111\/pim.12871","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T06:40:23Z","timestamp":1622011223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Higher frequency of circulating V\u03b41 \u03b3\u03b4T cells in patients with advanced schistosomiasis"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1126-0428","authenticated-orcid":false,"given":"Li","family":"Zheng","sequence":"first","affiliation":[{"name":"National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) Key Laboratory of Parasite and Vector Biology, National Health Commission of People's Republic of China WHO Collaborating Center for Tropical Diseases Shanghai China"},{"name":"Hubei Provincial Center for Disease Control and Prevention Hubei Provincial Academy of Preventive Medicine Hubei Provincial Key Laboratory for Applied Toxicology Wuhan China"},{"name":"Department of Immunology, Hainan Medical University Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Medical University\u2010The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases Haikou Hainan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Provincial Center for Disease Control and Prevention Hubei Provincial Academy of Preventive Medicine Hubei Provincial Key Laboratory for Applied Toxicology Wuhan 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