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The present study aimed to elucidate the effects and underlying molecular mechanisms of sertraline (SERT) on\n                    <jats:italic>T<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>gondii<\/jats:italic>\n                    \u2010induced depression\u2010like behaviours. In the present study, a mouse model and a microglial cell line (BV2 cells) model were established by infecting with the\n                    <jats:italic>T<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>gondii<\/jats:italic>\n                    RH strain. In\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    experiments, the underlying molecular mechanisms of SERT in inhibiting depression\u2010like behaviours and cellular perturbations caused by\n                    <jats:italic>T<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>gondii<\/jats:italic>\n                    infection were investigated in the mouse brain and BV2 cells. The administration of SERT significantly ameliorated depression\u2010like behaviours in\n                    <jats:italic>T<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>gondii<\/jats:italic>\n                    \u2010infected mice. Furthermore, SERT inhibited\n                    <jats:italic>T<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>gondii<\/jats:italic>\n                    proliferation. Treatment with SERT significantly inhibited the activation of microglia and decreased levels of pro\u2010inflammatory cytokines such as tumour necrosis factor\u2010alpha, and interferon\u2010gamma, by down\u2010regulating tumour necrosis factor receptor 1\/nuclear factor\u2010kappa B signalling pathway, thereby ameliorating the depression\u2010like behaviours induced by\n                    <jats:italic>T<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>gondii<\/jats:italic>\n                    infection. Our study provides insight into the underlying molecular mechanisms of the newly discovered role of SERT against\n                    <jats:italic>T<\/jats:italic>\n                    .\u00a0\n                    <jats:italic>gondii<\/jats:italic>\n                    \u2010induced depression\u2010like behaviours.\n                  <\/jats:p>","DOI":"10.1111\/pim.12893","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:37:13Z","timestamp":1634085433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["New role of sertraline against\n                    <i>Toxoplasma gondii<\/i>\n                    \u2010induced depression\u2010like behaviours in mice"],"prefix":"10.1111","volume":"43","author":[{"given":"Hui\u2010Wen","family":"Lan","sequence":"first","affiliation":[{"name":"Key Laboratory of Natural Resources of Changbai Mountain &amp; Functional Molecules Ministry of 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