{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:32:51Z","timestamp":1753878771846,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM110907"],"award-info":[{"award-number":["GM110907"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI139628"],"award-info":[{"award-number":["AI139628"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Signalling by IFN\u2010y and CD40 is known to trigger anti\u2010microbial activity in macrophages infected with <jats:italic>Toxoplasma gondii<\/jats:italic>, but their effects on infected neurons are less well known. Here, we compared how stimulation with IFN\u2010y and an agonistic anti\u2010CD40 mAb impacts infection and cyst formation in the mouse neuroblastoma cell line Neuro\u20102a relative to bone marrow\u2010derived macrophages. Both IFN\u2010y and CD40 mAb decreased cyst emergence in Neuro\u20102a cells. In macrophages, these stimuli decreased infection, but had no impact on infection in the neuroblastoma cell line. Resistance to killing in Neuro\u20102a cells may explain why neurons preferentially harbour parasites during chronic infection in the brain.<\/jats:p>","DOI":"10.1111\/pim.12897","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T17:14:51Z","timestamp":1636650891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of IFN\u2010y and CD40 signalling on <i>Toxoplasma gondii<\/i> cyst formation in differentiated Neuro\u20102a neuroblastoma cells"],"prefix":"10.1111","volume":"44","author":[{"given":"Claire M.","family":"Doherty","sequence":"first","affiliation":[{"name":"Center for Evolutionary and Theoretical Immunology and Department of Biology University of New Mexico  Albuquerque New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia D.","family":"Romero","sequence":"additional","affiliation":[{"name":"Center for Evolutionary and Theoretical Immunology and Department of Biology University of New Mexico  Albuquerque New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9020-3327","authenticated-orcid":false,"given":"Eric Y.","family":"Denkers","sequence":"additional","affiliation":[{"name":"Center for Evolutionary and Theoretical Immunology and Department of Biology University of New Mexico  Albuquerque New Mexico 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