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The diagnosis is hampered by variable sensitivity and\/or specificity of tests. In this context, prophylactic vaccination could represent a control measure against disease. In this study, the protective efficacy of\n                    <jats:italic>Leishmania<\/jats:italic>\n                    LiHyC protein was evaluated in a murine model against\n                    <jats:italic>Leishmania infantum<\/jats:italic>\n                    infection. LiHyC was used as recombinant protein (rLiHyC) associated with saponin (rLiHyC\/S) or Poloxamer 407\u2010based polymeric micelles (rLiHyC\/M) to immunize mice. Animals received also saline, saponin or empty micelles as controls. The immunogenicity was evaluated before and after the challenge, and results showed that vaccination with rLiHyC\/S or rLiHyC\/M induced the production of high levels of interferon\u2010gamma (IFN\u2010\u03b3), interleukin (IL)\u201012 and granulocyte\u2010macrophage colony\u2010stimulating factor in cell culture supernatants, as well as higher IFN\u2010\u03b3 expression evaluated by RT\u2010qPCR and involvement from CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell subtypes producing IFN\u2010\u03b3, tumor necrosis factor\u2010\u03b1 and IL\u20102. A positive lymphoproliferative response was also found in cell cultures from vaccinated animals, besides high levels of rLiHyC\u2010 and parasite\u2010specific nitrite and IgG2a antibodies. Immunological assays correlated with significant reductions in the parasite load in the spleens, livers, bone marrows and draining lymph nodes from vaccinated mice, when compared to values found in the controls. The micellar composition showed slightly better immunological and parasitological data, as compared to rLiHyC\/S. Results suggest that rLiHyC associated with adjuvants could be considered for future studies as a vaccine candidate against VL.\n                  <\/jats:p>","DOI":"10.1111\/pim.12921","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T22:03:01Z","timestamp":1650319381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<i>Leishmania<\/i>\n                    \u00a0\n                    <scp>LiHyC<\/scp>\n                    protein is immunogenic and induces protection against visceral leishmaniasis"],"prefix":"10.1111","volume":"44","author":[{"given":"Amanda S.","family":"Machado","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa do Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela P.","family":"Lage","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa do Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danniele L.","family":"Vale","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa do Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila S.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa do Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via P.","family":"Linhares","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa do Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamille M. O.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas\/NUPEB, Departamento de Ci\u00eancias Biol\u00f3gicas, Insituto de Ci\u00eancias Exatas e Biol\u00f3gicas Universidade Federal de Ouro Preto  Ouro Preto Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o A.","family":"Oliveira\u2010da\u2010Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa do Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela A. 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