{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:37:36Z","timestamp":1789472256457,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The chemokine receptor CCR7 is a well\u2010established homing receptor for dendritic cells (DCs) and T\u2010cells. Interaction with the CCL19 and CCL21 ligands promotes priming of immune responses in lymphoid tissues; however, the mechanism underlying CCR7\u2010induced immune responses against helminth parasite infection remains unknown. Thus, we examined the role of CCR7 in generating protective immune responses against intracellular\n                    <jats:italic>Trichinella spiralis<\/jats:italic>\n                    infection. The results showed significantly increased CCR7, CCL19 and CCL21 expression in the muscle tissue compared to that in the intestinal tissue in\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    \u2010infected mice. The CCR7\u2010expressing DC population increased in the mesenteric and peripheral lymph nodes (PLNs) during\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    infection. Notably, the number of CCR7\u2010expressing cells in PLNs increased by more than 30% at 28\u2009days post\u2010infection; however, this increase was significantly inhibited in CCR7\u2010blocked mice treated with CCR7\u2010specific antibodies. T helper 2 (Th2)\u2010and regulatory T (T\n                    <jats:sub>reg<\/jats:sub>\n                    )\u2010related cytokine levels were also reduced by CCR7\u2010specific antibody treatment. CCR7\u2010blocked mice lost their resistance to\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    infection in the muscle phase but not in the intestinal phase. Furthermore, fewer eosinophils around the nurse cells and reduced total and\n                    <jats:italic>T. spiralis\u2010<\/jats:italic>\n                    specific IgE in the serum were observed in CCR7\u2010blocked mice compared to those infected with only\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    . CCR7 blockade led to the\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    infection\u2010induced suppression of Th2\u2010 and T\n                    <jats:sub>reg<\/jats:sub>\n                    \u2010related cytokine production in vitro. These results suggest that CCR7 in DCs might play an essential role in host defence mechanisms against\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    infection, particularly in the muscle stage of the infection, by accelerating Th2 and T\n                    <jats:sub>reg<\/jats:sub>\n                    cell responses.\n                  <\/jats:p>","DOI":"10.1111\/pim.12938","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T14:28:26Z","timestamp":1654957706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Trichinella spiralis<\/i>\n                    nurse cell formation is regulated via CCR7\n                    <sup>+<\/sup>\n                    dendritic cells"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4992-1866","authenticated-orcid":false,"given":"Mi\u2010Kyung","family":"Park","sequence":"first","affiliation":[{"name":"Department of Parasitology and Tropical Medicine, School of Medicine Pusan National University  Yangsan\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9934-9787","authenticated-orcid":false,"given":"Shin Ae","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Tropical Medicine, School of Medicine Pusan National University  Yangsan\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Kyoung","family":"Cho","sequence":"additional","affiliation":[{"name":"Korean Medical Research Center for Healthy Aging Pusan National University  Yangsan\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak Sun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Tropical Medicine, School of Medicine Pusan National University  Yangsan\u2010si Republic of Korea"},{"name":"Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital  Yangsan\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.afnr.2018.04.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12412"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00192.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.2.1039"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00218-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/32588"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.767"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.100301.064828"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302358"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2015.53.4.431"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2297"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7346"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.3.1468"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061405"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062596"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.3.451"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80059-8"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.07.008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(99)00030-0"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00449-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3474"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/367183a0"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005347"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101980"}],"container-title":["Parasite 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