{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:47Z","timestamp":1772160887730,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012895","name":"Zoetis","doi-asserted-by":"publisher","award":["19ERGPAR\u201001\u201001"],"award-info":[{"award-number":["19ERGPAR\u201001\u201001"]}],"id":[{"id":"10.13039\/100012895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to collect information on local and systemic inflammatory responses, and goblet cell\u2010associated components, following anthelmintic treatment with moxidectin and ivermectin in horses naturally infected with cyathostomin parasites. Thirty\u2010six horses aged 2\u20135\u2009years of age were randomly allocated to three groups. Group 1 received ivermectin\/praziquantel (0.2\u00a0mg\/kg), Group 2 received moxidectin\/praziquantel (0.4\u00a0mg\/kg) and Group 3 were untreated controls. Tissue samples from the Cecum, Dorsal and Ventral Colons were used for histopathological evaluation and preserved for RNA isolation and gene expression analysis. Whole blood was collected weekly for gene expression analysis as well. The control group had significantly higher inflammation associated with higher larval scores. The treatment groups displayed no differences in larval counts and inflammatory cell populations (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u2009.05). Mucosal larval counts were positively correlated with goblet cell hyperplasia scores (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.047). The moxidectin\u2010treated group had a significantly lower expression of IFN\u2010\u03b3 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). The data suggest that removal of cyathostomins reduced the pro\u2010inflammatory response associated with cyathostomin infections. Pro\u2010inflammatory reactions associated with anthelmintic treatment were minimal, but lowest for moxidectin\u2010treated horses. Results suggested that cecum, ventral and dorsal colons responded differently to cyathostomin larvae, which may have implications in the disease process.\n                  <\/jats:p>","DOI":"10.1111\/pim.12941","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T03:10:04Z","timestamp":1658027404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of the host response to larvicidal and nonlarvicidal treatment of naturally acquired cyathostomin infections in horses"],"prefix":"10.1111","volume":"44","author":[{"given":"Ashley E.","family":"Steuer","sequence":"first","affiliation":[{"name":"Maxwell H. Gluck Equine Research Center, Department of Veterinary Science University of Kentucky  Lexington Kentucky USA"},{"name":"Texas Tech University School of Veterinary Medicine  Amarillo Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1348-641X","authenticated-orcid":false,"given":"Kirsten","family":"Scoggin","sequence":"additional","affiliation":[{"name":"Maxwell H. Gluck Equine Research Center, Department of Veterinary Science University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Maxwell H. Gluck Equine Research Center, Department of Veterinary Science University of Kentucky  Lexington Kentucky USA"},{"name":"Lexar Laboratories  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia D.","family":"Barker","sequence":"additional","affiliation":[{"name":"Maxwell H. Gluck Equine Research Center, Department of Veterinary Science University of Kentucky  Lexington Kentucky USA"},{"name":"Lexar Laboratories  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda A.","family":"Adams","sequence":"additional","affiliation":[{"name":"Maxwell H. Gluck Equine Research Center, Department of Veterinary Science University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan T.","family":"Loynachan","sequence":"additional","affiliation":[{"name":"University of Kentucky Veterinary Diagnostic Laboratory University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8942-6803","authenticated-orcid":false,"given":"Martin K.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Maxwell H. Gluck Equine Research Center, Department of Veterinary Science University of Kentucky  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(03)00239-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(97)00095-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1986.tb03564.x"},{"key":"e_1_2_10_5_1","unstructured":"VerkaaikL.Species distribution of encysted cyathostome larvae and attribution of cyathostome species to larval cyathostominosis in The Netherlands.2016;1\u201347."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2008.04.026"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)31879-4"},{"key":"e_1_2_10_8_1","first-page":"327","article-title":"Strongyle infections in ponies. 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