{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:57:28Z","timestamp":1787579848116,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Florida Native is a heritage sheep breed in the United States and expresses superior ability to regulate gastrointestinal nematodes. The objective of the present study was to investigate the importance of copy number variants (CNVs) on resistance to natural\n                    <jats:italic>Haemonchus contortus<\/jats:italic>\n                    infections. A total of 300 Florida Native sheep were evaluated. Phenotypic records included fecal egg count (FEC, eggs\/gram), FAMACHA\u00a9 score, percentage cell volume (PCV, %), body condition score (BCS) and average daily gain (ADG, kg). Sheep were genotyped using the GGP Ovine 50K single nucleotide polymorphism (SNP) chip. Log ratios from 45.2\u2009k SNP markers spanning the entire genome were utilized for CNV detection. After quality control, 261 animals with CNVs and phenotypic records were used for the association testing. Association tests were carried out using correlation\u2010trend test and principal component analysis correction to identify CNVs associated with FEC, FAMACHA\u00a9, PCV, BCS and ADG. Significant CNVs were detected when their adjusted\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value was &lt;.05 after FDR correction. A total of 8124 CNVs were identified, which gave 246 non\u2010overlapping CNVs. Fourteen CNVs were significantly associated with FEC and PCV. CNVs associated with FEC overlapped 14 Quantitative Trait Locus previously associated with\n                    <jats:italic>H. contortus<\/jats:italic>\n                    resistance. Our study demonstrated for the first time that CNVs could be potentially involved with parasite resistance in Florida Native sheep. Immune\u2010related genes such as\n                    <jats:italic>CCL1<\/jats:italic>\n                    ,\n                    <jats:italic>CCL2<\/jats:italic>\n                    ,\n                    <jats:italic>CCL8<\/jats:italic>\n                    ,\n                    <jats:italic>CCL11<\/jats:italic>\n                    ,\n                    <jats:italic>NOS2<\/jats:italic>\n                    ,\n                    <jats:italic>TNF<\/jats:italic>\n                    ,\n                    <jats:italic>CSF3<\/jats:italic>\n                    and\n                    <jats:italic>STAT3<\/jats:italic>\n                    genes could play an important role for controlling\n                    <jats:italic>H. contortus<\/jats:italic>\n                    resistance. These genes could be potentially utilized as candidate markers for selection of parasite resistance in this breed.\n                  <\/jats:p>","DOI":"10.1111\/pim.12943","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T23:43:42Z","timestamp":1660866222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Copy number variant\u2010based genome wide association study reveals immune\u2010related genes associated with parasite resistance in a heritage sheep breed from the United States"],"prefix":"10.1111","volume":"44","author":[{"given":"Zaira M.","family":"Estrada\u2010Reyes","sequence":"first","affiliation":[{"name":"Department of Animal Sciences North Carolina A&amp;T State University  Greensboro North Carolina USA"},{"name":"Department of Animal Sciences University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibukun M.","family":"Ogunade","sequence":"additional","affiliation":[{"name":"Division of Animal and Nutritional Science West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres A.","family":"Pech\u2010Cervantes","sequence":"additional","affiliation":[{"name":"College of Agricultural, Family Sciences, and Technology Fort Valley State University  Fort Valley Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Terrill","sequence":"additional","affiliation":[{"name":"College of Agricultural, Family Sciences, and Technology Fort Valley State University  Fort Valley Georgia 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