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It is caused by the larval stage of the dog tapeworm \u201c\n                    <jats:italic>Echinococcus granulosussensu lato<\/jats:italic>\n                    \u201d and constitutes a major economic and public health problem in several countries. Protoscoleces are one component of this larval stage that can interact with both definitive and intermediate hosts. The aim of the present study was to investigate the potential role of using a radio\u2010attenuated form of these protoscoleces for immunoprophylaxis against experimental murine echinococcosis. However, mice were immunized twice at 15\u2010day intervals with gamma (\u03b3) irradiated protoscoleces at doses of 0.4, 0.8, 1.2 and 1.4\u00a0kGy then challenged with the intact parasites. Macroscopic and histological analyses with cytokine measurements were performed in order to estimate the number and diameter of cysts, microscopic changes and cytokine profile. An improvement in protection against the challenge dose was observed with increasing dose, giving percentages of 47.7, 49, 55.23 and 70.6%, for the 0.4, 0.8, 1.2 and 1.4\u00a0kGy\u2010groups respectively. These data suggest that immunization with radio\u2010attenuated protoscoleces may induce satisfactory protective immunity by reducing successfully the formation of cysts, caused by challenge infection.\n                  <\/jats:p>","DOI":"10.1111\/pim.12944","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T01:35:39Z","timestamp":1660095339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of protoscoleces with gamma radiation: Potential immunoprotective effect against experimental murine echinococcosis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7722-485X","authenticated-orcid":false,"given":"Samia","family":"Hadj Rabia","sequence":"first","affiliation":[{"name":"Department of Nuclear Applications Nuclear Research Center Draria Algeria"},{"name":"Laboratory of Biology and Animal Physiology ENS Kouba Algiers 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