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The disease causes a serious granulomatous inflammatory response that produces significant mortality. Plumbagin reportedly displays anti\u2010inflammatory, anti\u2010fibrotic, antioxidant and anthelmintic properties. This study further elucidates these properties. Mice were infected with schistosomes and divided into five groups: non\u2010infected untreated (C); infected untreated (IU); non\u2010infected treated with plumbagin (P); infected treated with plumbagin (PI) and infected treated with praziquantel (PZ). Mice treated with 20\u2009mg plumbagin\/kg body weight showed reduction of 64.28% and 59.88% in male and female animals, respectively. Also, the number of eggs\/g tissue was reduced 69.39%, 68.79% and 69.11% in liver, intestine and liver\/intestine combined, respectively. Plumbagin alleviated schistosome\u2010induced hepatosplenomegaly and reduced hepatic granuloma and liver collagen content by 62.5% and 35.26%, respectively while PZQ reduced hepatic granuloma and liver collagen content by 41.11% and 11.21%, respectively. Further, plumbagin treatment significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) reduced IL\u20104, IL\u201013, IL\u201017, IL\u201037, IFN\u2010\u03b3, TGF\u2010\u03b2 and TNF\u2010\u03b1 levels and significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) upregulated IL\u201010. Plumbagin treatment restored hepatic enzymes activity to nearly normal levels and induced an increase in catalase, SOD, GSH, total thiol and GST in liver tissue homogenate. NO and LPO content was, however, decreased. Moreover, serum IgG levels significantly increased. The present study is the first to report immunomodulatory and schistosomicidal activities of plumbagin in schistosomiasis.<\/jats:p>","DOI":"10.1111\/pim.12945","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T16:07:41Z","timestamp":1660234061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Anti\u2010inflammatory, antioxidant, anti\u2010fibrotic and schistosomicidal properties of plumbagin in murine schistosomiasis"],"prefix":"10.1111","volume":"44","author":[{"given":"Heba H.","family":"Bakery","sequence":"first","affiliation":[{"name":"Immunology Divisions, Zoology Department, Faculty of Science Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal A.","family":"Allam","sequence":"additional","affiliation":[{"name":"Immunology Divisions, Zoology Department, Faculty of Science Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelaziz S. 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