{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:48Z","timestamp":1772160888693,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2662017JC027"],"award-info":[{"award-number":["2662017JC027"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Haemonchus contortus<\/jats:italic>\n                    (\n                    <jats:italic>H<\/jats:italic>\n                    .\n                    <jats:italic>contortus<\/jats:italic>\n                    ) has caused a huge impact on the animal husbandry economy in the world's tropical and subtropical regions. Innate immunity is the first\u2010line of host defence. The host recognizes pathogen\u2010associated molecular patterns (PAMPs) through a variety of pattern recognition receptors (PRRs) and activates downstream signalling pathways to resist pathogens invasion. Therefore, elucidating the immune interaction between host and pathogen is key to understanding how the host resists the pathogen. We identified 1516 protein\u2013protein interactions (PPIs) between goat innate immune signal pathway proteins and\n                    <jats:italic>H<\/jats:italic>\n                    .\n                    <jats:italic>contortus<\/jats:italic>\n                    excretory\u2010secretory proteins (ESPs) by Recombination\u2010based \u201cLibrary vs. Library\u201d yeast two\u2010hybrid system (RLL\u2010Y2H) and constructed the PPIs network. Among them, the NLR and IL\u201017 signalling pathways have the most protein interactions. And there were more interaction proteins between NOD1 and MUC5AC proteins in the pathways. Combined with the differentially expressed genes (DEGs) of susceptible and resistant goats identified in the preliminary work of our laboratory, we selected the intersection genes to construct the PPIs network, and TRAF2 appeared as a key protein of goat innate immune signalling pathway. We initially studied the PPIs between goat and\n                    <jats:italic>H. contortus<\/jats:italic>\n                    ESPs, which provides valuable information for better understanding the immune interaction between the goats and the\n                    <jats:italic>H. contortus<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/pim.12950","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T22:10:26Z","timestamp":1663193426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protein interactions network of goat innate immune signalling pathway proteins and\n                    <i>Haemonchus contortus<\/i>\n                    excretory\u2010secretory proteins"],"prefix":"10.1111","volume":"44","author":[{"given":"Wenxuan","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Smart Animal Farming Technology, Ministry of Agriculture Huazhong Agricultural University  Wuhan China"},{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics Huazhong Agricultural University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanghui","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Smart Animal Farming Technology, Ministry of Agriculture Huazhong Agricultural University  Wuhan China"},{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics Huazhong Agricultural University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Smart Animal Farming Technology, Ministry of Agriculture Huazhong Agricultural University  Wuhan China"},{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics Huazhong Agricultural University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoxin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Smart Animal Farming Technology, Ministry of Agriculture Huazhong Agricultural University  Wuhan China"},{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics Huazhong Agricultural University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Smart Animal Farming Technology, Ministry of Agriculture Huazhong Agricultural University  Wuhan China"},{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics Huazhong Agricultural University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Smart Animal Farming Technology, Ministry of Agriculture Huazhong Agricultural University  Wuhan China"},{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics Huazhong Agricultural University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Kong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Smart Animal Farming Technology, Ministry of Agriculture Huazhong Agricultural University  Wuhan China"},{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics Huazhong Agricultural University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Lab of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Technology Huazhong Agricultural University  Wuhan China"},{"name":"Wuhan Academy of Agricultural Sciences Institute of Animal Science and Veterinary Medicine  Wuhan 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