{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:34:43Z","timestamp":1782369283841,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","award":["SUS0024\/2018"],"award-info":[{"award-number":["SUS0024\/2018"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Strongyloidiasis control is associated with a Th2 immune response. However, alcohol ingestion plays an important role in modulating the immune system. The aim of this study is to evaluate the occurrence of\n                    <jats:italic>Strongyloides stercoralis<\/jats:italic>\n                    infection in alcoholic patients, the levels of circulating cytokines (IFN\u2010\u03b3, IL\u20102, IL\u20104, IL\u20105, IL\u201010, IL\u201015 and IL\u201017), and its correlation with modulation of parasitic load in alcoholic individuals infected with\n                    <jats:italic>S. stercoralis<\/jats:italic>\n                    . A total of 336 alcoholic patients, treated at the Alcoholic Care and Treatment Center\u00a0were included in this study. The cytokine levels were measured by a commercial ELISA in 80 sera divided into four groups with 20 individuals each: alcoholics infected (ASs+) and not infected (ASs\u2010) with\n                    <jats:italic>S. stercoralis<\/jats:italic>\n                    and non\u2010alcoholics infected (NASs+) and not infected (NASs\u2010) with the helminth.\n                    <jats:italic>S. stercoralis<\/jats:italic>\n                    frequency in alcoholic patients was 16.1% (54\/336). The parasitic load varied from 1 to 546 larvae\/g of faeces, median and interquartile range (IQR) of 9 and 1.0\u201362.5 larvae\/g of faeces, while in non\u2010alcoholic individuals the parasitic load was less than 10 larvae\/g of faeces. Levels of circulating IL\u20104 were significantly higher in ASs+ when compared with NASs\u2010 group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). An inverse correlation between serum levels of IFN\u2010\u03b3 and parasitic load in alcoholic patients infected with\n                    <jats:italic>S. stercoralis<\/jats:italic>\n                    was observed (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u2212601;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). These results suggest that modulation of IFN\u2010\u03b3 production occurs in alcoholic individuals with high parasitic burden.\n                  <\/jats:p>","DOI":"10.1111\/pim.12977","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T03:47:55Z","timestamp":1678247275000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Modulation of circulating cytokine production in alcoholic patients infected with\n                    <i>Strongyloides stercoralis<\/i>"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-3223","authenticated-orcid":false,"given":"Alex Bruno da Silva","family":"Souza","sequence":"first","affiliation":[{"name":"Faculdade de Farm\u00e1cia Universidade Federal da Bahia (UFBA)  Salvador 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