{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:43:02Z","timestamp":1753879382119,"version":"3.41.2"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003121","name":"Ferdowsi University of Mashhad","doi-asserted-by":"publisher","award":["46351"],"award-info":[{"award-number":["46351"]}],"id":[{"id":"10.13039\/501100003121","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is now sufficient evidence to support an inverse association between helminth infection and secreted products with allergic\/autoimmune disorders. Accordingly, several experimental studies have shown that <jats:italic>Echinococcus granulosus<\/jats:italic> infection and hydatid cyst compounds are able to suppress immune responses in allergic airway inflammation. This is the first study on effects of somatic antigens of <jats:italic>E. granulosus<\/jats:italic> on chronic allergic airway inflammation in BALB\/c mice. Mice in OVA group were intraperitoneally (IP) sensitized with OVA\/Alum. Subsequently, were challenged by nebulizing of OVA 1%. The treatment groups received somatic antigens of protoscoleces on the specified days. Mice in PBS group were received PBS in both sensitization and challenge. The effects of somatic products on development of chronic allergic airway inflammation were evaluated by examining histopathological changes, the recruitment of inflammatory cells in the bronchoalveolar lavage, cytokines production in the homogenized lung tissue, and total antioxidant capacity in serum. Our findings show that the co\u2010administration of somatic antigens of protoscoleces simultaneously with the development of asthma intensifies allergic airway inflammation. The identification of effective components involved in exacerbation of allergic airway inflammation manifestations will be a crucial approach to understanding the mechanism of these interactions.<\/jats:p>","DOI":"10.1111\/pim.12985","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T07:22:34Z","timestamp":1686295354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The mouse model of chronic asthma: Airway remodelling and disease exacerbation by somatic antigen of <i>Echinococcus granulosus<\/i>"],"prefix":"10.1111","volume":"45","author":[{"given":"Sara","family":"Ghabdian","sequence":"first","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sima","family":"Parandeh Shirvan","sequence":"additional","affiliation":[{"name":"Genetic Labratory Department of the Eniviroment  Banddar\u2010Abbas Hormozgan province Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Maleki","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4706-4995","authenticated-orcid":false,"given":"Hassan","family":"Borji","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine Ferdowsi University of Mashhad  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2017.07.013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2006.02.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.26855\/ijcemr.2022.04.005"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"121","article-title":"Immunology of cystic echinococcosis (hydatid disease)","volume":"124","author":"D\u00edaz \u00c1","year":"2017","journal-title":"Br Med Bull"},{"issue":"1","key":"e_1_2_10_6_1","first-page":"36","article-title":"Cystic echinococcosis","volume":"14","author":"Prousalidis J","year":"2009","journal-title":"Surg Chronicles"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02463.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0026893317020030"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.14.0170"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02106"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:26:1:15"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2002.00497.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-014-0522-6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071\u2010016\u20101350\u20107"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2019.02.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-5-S2-P17"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2930434"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.8.4552-4560.2004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00191.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:26:1:35"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-331OC"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00533-18"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12513"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.12.609"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2020.101488"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.09.005"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2018.07.016"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.03.014"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00061"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3967\/0895\u20103988.2012.06.015"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb05569.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb03778.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00843.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01807.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.1.288-296.2001"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1997.d01-222.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1999.00246.x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-004-0004-2"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00263"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900164"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.7879"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13052"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03852.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.76"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12540"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-200044774"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5149"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2020.1870129"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071\u2010021\u201005125\u20102"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.12985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T19:44:50Z","timestamp":1692474290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.12985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,9]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/pim.12985"],"URL":"https:\/\/doi.org\/10.1111\/pim.12985","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"type":"print","value":"0141-9838"},{"type":"electronic","value":"1365-3024"}],"subject":[],"published":{"date-parts":[[2023,6,9]]},"assertion":[{"value":"2022-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12985"}}