{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:46Z","timestamp":1772160886079,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF15OC0016406"],"award-info":[{"award-number":["NNF15OC0016406"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Intestinal tuft cells have been shown to induce type 2 immune responses during viable parasite infections, but whether oral supplementation with a parasitic exudate is able to promote type 2 immune responses that have been shown to positively regulate obesogenic metabolic processes is yet unresolved. High\u2010fat fed mice were gavaged with pseudocoelomic fluid (PCF) derived from the helminth\n                    <jats:italic>Ascaris suum<\/jats:italic>\n                    or saline thrice a week during weeks 5\u20139, followed by examination of intestinal tuft cell activity, immune, and metabolic parameters. Helminth PCF upregulated expression of distinct genes in small intestinal tuft cells, including genes involved in regulation of RUNX1 and organic cation transporters. Helminth PCF also enhanced levels of innate lymphoid cells in the ileum, and eosinophils in epididymal white adipose tissue (eWAT). Network analyses revealed two distinct immunometabolic cues affected by oral helminth PCF in high\u2010fat fed mice: one coupling the small intestinal tuft cell responses to the fat\u2010to\u2010lean mass ratio and a second coupling eosinophils in eWAT to general regulation of body fat mass. Our findings point to specific mechanisms by which oral supplementation with helminth PCF may translate into systems\u2010wide effects linking to reduced body and fat mass gain in mice during high\u2010fat feeding.\n                  <\/jats:p>","DOI":"10.1111\/pim.12998","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T11:57:39Z","timestamp":1686139059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oral administration of helminth fluid modulates distinct tuft cell and immune\u2010metabolic cues linked to reduced body fat"],"prefix":"10.1111","volume":"45","author":[{"given":"Daniel","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Biomedicine Technical University of Denmark  Kongens Lyngby Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janne 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