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Phenotypic parameters and local responses were evaluated in sheep from two \u03b2\u2010globin haplotypes naturally infected with\n                    <jats:italic>Haemonchus contortus<\/jats:italic>\n                    . Morada Nova lambs were monitored at 63, 84 and 105\u2009days of age for faecal egg counts and packed cell volume (PCV) under natural infection with\n                    <jats:italic>H. contortus<\/jats:italic>\n                    . At 210\u2009days of age, lambs of Hb\u2010AA and Hb\u2010BB \u03b2\u2010globin haplotypes were euthanised, and the fundic region of abomasum was sampled for evaluation of microscopic lesions and relative expression of genes related to immune, mucin and lectin activities. Lambs harbouring the \u03b2\n                    <jats:sup>A<\/jats:sup>\n                    allele presented an improved resistance\/resilience against clinical haemonchosis, showing higher PCV during infection. Hb\u2010AA animals presented increased eosinophilia in the abomasum compared to Hb\u2010BB animals, accompanied by higher Th2 profile, mucin and lectin activity transcripts, while the inflammatory response was increased in Hb\u2010BB animals. This is the first report to demonstrate an enhanced local response in the primary site of\n                    <jats:italic>H. contortus<\/jats:italic>\n                    infection related to \u03b2\n                    <jats:sup>A<\/jats:sup>\n                    allele of \u03b2\u2010globin haplotype.\n                  <\/jats:p>","DOI":"10.1111\/pim.13003","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T19:55:18Z","timestamp":1688414118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Enhanced mucosal response in sheep harbouring\n                    <scp>\n                      \u03b2\n                      <sup>A<\/sup>\n                    <\/scp>\n                    beta\u2010globin against haemonchosis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3692-3902","authenticated-orcid":false,"given":"Cintia 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