{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:40:13Z","timestamp":1790354413862,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","award":["93016151"],"award-info":[{"award-number":["93016151"]}],"id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Toxocara canis<\/jats:italic> is a global zoonosis infection that can cause chronic and long\u2010term toxocariasis in their paratenic host. The excretory\u2010secretory (ES) products of <jats:italic>T<\/jats:italic>. <jats:italic>canis<\/jats:italic> larvae are considered to be responsible for the Th2 polarization and regulatory immune responses in toxocariasis. The C\u2010type lectin family is one of the most prominent components of ES products of <jats:italic>T<\/jats:italic>. <jats:italic>canis<\/jats:italic> infective larvae. This study aimed to investigate the ameliorative effect of a <jats:italic>T<\/jats:italic>. <jats:italic>canis<\/jats:italic> C\u2010type lectin recombinant protein (rCTL), on experimental autoimmune encephalomyelitis (EAE) which is a T\u2010cell\u2010mediated autoimmune disease of the central nervous system. C57BL\/6 mice were subcutaneously treated with 30\u2009\u03bcg rCTL, three times at an interval of 1\u2009week. EAE was induced by myelin oligodendrocyte glycoprotein 35\u201355 peptide (MOG35\u201055 peptide) immunization, and weight and clinical scores were evaluated. Real time polymerase chain reaction was performed to evaluate the expression levels of <jats:italic>T<\/jats:italic>\u2010<jats:italic>bet<\/jats:italic>, <jats:italic>Gata3<\/jats:italic>, and <jats:italic>Foxp3<\/jats:italic> in splenocytes. In addition, the levels of interleukin 4, interferon gamma, and tumour growth factor\u2010\u03b2 (TGF\u2010\u03b2) were quantified by enzyme\u2010linked immunosorbent assay in splenocyte culture supernatants. The results indicated that the rCTL decreased clinical disability scores and delayed the onset of EAE. Furthermore, the data showed that rCTL treatment modulated the immune response, which was associated with upregulation of the mRNA expression of the <jats:italic>Foxp3<\/jats:italic> gene and higher production of TGF\u2010\u03b2 in rCTL\u2010treated mice. This study demonstrated that rCTL might be a potential agent to ameliorate EAE symptoms by stimulating anti\u2010inflammatory responses.<\/jats:p>","DOI":"10.1111\/pim.13010","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T08:10:18Z","timestamp":1695024618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The immunomodulatory effects of the <scp>C\u2010<\/scp>type lectin protein of <i>Toxocara canis<\/i> on experimental autoimmune encephalomyelitis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-832X","authenticated-orcid":false,"given":"Fazeleh","family":"Etebar","sequence":"first","affiliation":[{"name":"Faculty of Health, Centre for Immunology and Infection Control Queensland University of Technology  Kelvin Grove Queensland Australia"},{"name":"Department of Parasitology, Faculty of Veterinary Medicine Tehran University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hossein","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Veterinary Medicine Tehran University  Tehran Iran"},{"name":"Iranian Museum of Parasitology, Faculty of Veterinary Medicine Tehran University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Borhani Zarandi","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdorreza Naser","family":"Moghadasi","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Research Center Neuroscience institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fateme","family":"Jalousian","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Veterinary Medicine Tehran University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34261"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.09.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60568-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000768"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.01.055"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21092"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:26:1:15"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0306-7"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.615192"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00191.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-093019-122827"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02128"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.572865"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2009.04.008"},{"key":"e_1_2_11_16_1","article-title":"TLRs, Treg, and B cells, an interplay of regulation during helminth","volume":"3","author":"Layland L","year":"2012","journal-title":"Infection"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-018-0437-0"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4238\/vol7-2gmr443"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2012.12.032"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12672"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009639"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2001.00387.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2010.10.005"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80366-2"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12175"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-017-5544-5"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520970841"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13819"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52001-2.00008-X"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519899040"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.9.4996-5004.2003"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01830"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0680"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102141"},{"issue":"1","key":"e_1_2_11_35_1","first-page":"49","article-title":"Phylogenetic analysis of C type lectin from Toxocara canis infective larvae and comparison with the C type lectin family in the immune system of mouse and human","volume":"13","author":"Etebar F","year":"2018","journal-title":"Iran J Parasitol"},{"issue":"1","key":"e_1_2_11_36_1","first-page":"143","article-title":"Recombinant C\u2010type lectin protein of Toxocara canis increases the population of spleen Foxp3+ regulatory T cells in BALB\/c mice","volume":"68","author":"Shahbakhsh M","year":"2022","journal-title":"Ann Parasitol"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02349"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1118"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511418027"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37789"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100834"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12760"},{"issue":"2","key":"e_1_2_11_43_1","first-page":"175","article-title":"Evaluate Toxocara canis excretory\u2010secretory antigens in experimental allergic encephalomyelitis (EAE)","volume":"11","author":"Borhani zarandi M","year":"2017","journal-title":"Iran J Vet Med"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxg012"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101074"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.6456"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838727"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.11.016"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh390"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11541"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518763094"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501097"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21067"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2011.01.002"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803803"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2011.12.006"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1689-8"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2010.01240.x"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2010.06.014"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12594"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.13010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T19:51:18Z","timestamp":1696535478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.13010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,18]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/pim.13010"],"URL":"https:\/\/doi.org\/10.1111\/pim.13010","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,18]]},"assertion":[{"value":"2023-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13010"}}