{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:33:22Z","timestamp":1788910402314,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["MCTI 14\/2014 #454136\/2014\u20105"],"award-info":[{"award-number":["MCTI 14\/2014 #454136\/2014\u20105"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A role of IL\u201010 is down\u2010regulating T\u2010cell responses to schistosome antigens. Since SmATPDases can be correlated to modulation of the immune response, we evaluated the expression of enzymes in\n                    <jats:italic>S.\u2009mansoni<\/jats:italic>\n                    eggs. Faecal samples were collected from 40 infected individuals to detect coding regions of the SmATPDases. The cytokines were measured in supernatants of PBMC. The analysis was performed by the global median determination and set up high producers (HP) of cytokines. Six individuals expressed SmATPDase1, six expressed SmATPDase2 and six expressed both enzymes. The group who expressed only SmATPDase1 showed a high frequency of IFN\u2010\u03b3, TNF IL\u20104 HP; individuals who expressed only SmATPDase2 showed a high frequency of IFN\u2010\u03b3, IL\u20106 and IL\u20104 HP; and individuals who expressed both enzymes showed a high frequency of IL\u201010 HP. The comparison of the IFN\u2010\u03b3\/IL\u201010 ratio presented higher indices in the group who had SmATPDase 2 expression than those who had the expression of both enzymes. The positive correlation between infection intensity and IL\u201010 levels remained only in the positive SmATPDase group. The IL\u201010 is the only cytokine induced by the expression of both enzymes. Our data suggest that the expression of both enzymes seems to be a factor that modulates the host immune response by inducing high IL\u201010 production.\n                  <\/jats:p>","DOI":"10.1111\/pim.13017","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T17:26:00Z","timestamp":1699032360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Expression of\n                    <scp>SmATPDases<\/scp>\n                    1 and 2 in\n                    <i>Schistosoma mansoni<\/i>\n                    eggs favours\n                    <scp>IL<\/scp>\n                    \u201010 production in infected individuals"],"prefix":"10.1111","volume":"46","author":[{"given":"Thalisson Artur Ribeiro","family":"Gomides","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunoparasitologia, Departamento de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Ouro Preto  Ouro 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