{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:16:59Z","timestamp":1789168619177,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The immunomodulatory potential of the excretory\u2010secretory (E\/S) proteins of the helminths has been shown in previous investigations. This study evaluated the effects of the recombinants and excretory\u2010secretory proteins of the <jats:italic>Fasciola hepatica<\/jats:italic> on induced colitis in Balb\/c mice. The <jats:italic>F. hepatica<\/jats:italic> Recombinant proteins, Cathepsin L1 and Peroxiredoxin, and E\/S proteins were intraperitoneally injected into the three mice groups as the case groups, while the control groups received PBS. Colitis was induced in mice by intraluminal administration of the 2, 4, 6\u2010Trinitrobenzenesulfonic acid solution (TNBS). After 8\u2009h, the case groups received the second dosage of the treatments, and it was repeated 24\u2009h later. The immunological, pathological, and macroscopic changes were evaluated 3\u2009days after colitis induction. The macroscopic evaluation revealed significantly lower inflammatory scores in the mice treated with recombinant Peroxiredoxin (rPRX) and recombinant Cathepsin L1 (rCL1). Despite the macroscopic observation, the pathological finding was insignificant between the groups. IFN\u2010\u03b3 secretion was significantly lower in splenocytes of the groups that received rPRX, rCL1, and E\/S than the controls. IL\u201010 showed significantly higher levels in groups treated with rPRX and rCL1 than controls, whereas the level of IL\u20104 was not statistically significant. Excretory\u2010secretory proteins of the <jats:italic>F. hepatica<\/jats:italic> showed immunomodulatory potency and the main effects observed in this study were through the reduction of inflammatory cytokine and inflammation manifestation as well as induction of anti\u2010inflammatory cytokines.<\/jats:p>","DOI":"10.1111\/pim.13019","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T14:20:52Z","timestamp":1705587652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effects of <i>Fasciola hepatica<\/i> recombinant proteins (peroxiredoxin and cathepsin <scp>L1<\/scp>) on Crohn's disease experimental model"],"prefix":"10.1111","volume":"46","author":[{"given":"Hamid","family":"Hasanpour","sequence":"first","affiliation":[{"name":"Department of Parasitology and Mycology, School of Allied Medical Sciences Ilam University of Medical Sciences  Ilam Iran"},{"name":"Zoonotic 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