{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:35:00Z","timestamp":1778506500419,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ticks are notorious blood\u2010sucking ectoparasites that affect both humans and animals. They serve as a unique vector of various deadly diseases. Here, we have shown the roles of the receptor for advanced glycation end products (RAGE) during repeated infestations by the tick\n                    <jats:italic>Haemaphysalis longicornis<\/jats:italic>\n                    using\n                    <jats:italic>RAGE<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice. In primary infestation, a large blood pool developed, which was flooded with numerous RBCs, especially during the rapid feeding phase of the tick both in wild\u2010type (wt) and\n                    <jats:italic>RAGE<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice. Very few inflammatory cells were detected around the zones of haemorrhage in the primary infestations. However, the number of inflammatory cells gradually increased in the subsequent tick infestations, and during the third infestations, the number of inflammatory cells reached to the highest level (350.3\u2009\u00b1\u200916.8 cells\/focus). The site of attachment was totally occupied by the inflammatory cells in wt mice, whereas very few cells were detected at the ticks' biting sites in\n                    <jats:italic>RAGE<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice. RAGE was highly expressed during the third infestation in wt mice. In the third infestation, infiltration of CD44\n                    <jats:sup>+<\/jats:sup>\n                    lymphocytes, eosinophils and expression of S100A8 and S100B significantly increased at the biting sites of ticks in wt, but not in\n                    <jats:italic>RAGE<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. In addition, peripheral eosinophil counts significantly increased in wt but not in\n                    <jats:italic>RAGE<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Taken together, our study revealed that RAGE\u2010mediated inflammation and eosinophils played crucial roles in the tick\u2010induced inflammatory reactions.\n                  <\/jats:p>","DOI":"10.1111\/pim.13039","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T07:20:02Z","timestamp":1717572002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Receptor for Advanced Glycation End Product (\n                    <scp>RAGE<\/scp>\n                    ) Modulates Inflammation During Feeding of the Hard Tick,\n                    <i>Haemaphysalis longicornis<\/i>\n                    in Mice"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7350-3093","authenticated-orcid":false,"family":"Anisuzzaman","sequence":"first","affiliation":[{"name":"Department of Parasitology, Faculty of Veterinary Science Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0021-2604","authenticated-orcid":false,"given":"Md.\u00a0Abdul","family":"Alim","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Veterinary Science Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7182-4280","authenticated-orcid":false,"given":"Makoto","family":"Matsubyashi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Immunology Graduate School of Veterinary Sciences, Osaka Metropolitan University  Izumisano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6176-1036","authenticated-orcid":false,"given":"Md.\u00a0Shahadat","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Veterinary Science Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6500-7067","authenticated-orcid":false,"given":"Sharmin\u00a0Shahid","family":"Labony","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Veterinary Science Bangladesh Agricultural University  Mymensingh Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7103-6786","authenticated-orcid":false,"given":"Ireen\u00a0Sultana","family":"Shanta","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0624-8055","authenticated-orcid":false,"given":"Md.\u00a0Haydar","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Veterinary Science Bangladesh Agricultural University  Mymensingh Bangladesh"},{"name":"Department of Pathology and Parasitology, Faculty of Veterinary and Animal Science Hajee Mohammad Danesh Science and Technology University (HSTU)  Dinajpur Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Vascular Biology Kanazawa University Graduate School of Medical Sciences  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hatta","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Tropical Medicine Kitasato University School of Medicine  Sagamihara Japan"},{"name":"Laboratory of Parasitic Diseases National Institute of Animal Health, National Agricultural and Food Research Organization  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-1316","authenticated-orcid":false,"given":"Naotoshi","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Tropical Medicine Kitasato University School of Medicine  Sagamihara Japan"},{"name":"Laboratory of Parasitic Diseases National Institute of Animal Health, National Agricultural and Food Research Organization  Tsukuba 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