{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:04:46Z","timestamp":1789243486727,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS098891"],"award-info":[{"award-number":["R01NS098891"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Neurocysticercosis (NCC), a major cause of global acquired epilepsy, results from <jats:italic>Taenia solium<\/jats:italic> larval brain infection. <jats:italic>T. solium<\/jats:italic> adult worms release large numbers of infective eggs into the environment contributing to high levels of exposure in endemic areas. This study identifies <jats:italic>T. solium<\/jats:italic> proteins in the sera of individuals with and without NCC using mass spectrometry to examine exposure in endemic regions. Forty\u2010seven patients (18\u201351\u2009years), 24 parenchymal NCC (pNCC), 8 epilepsy of unknown aetiology, 7 glioma, 8 brain tuberculoma, and 7 healthy volunteers were studied. Trypsin digested sera were subject to liquid chromatography\u2013tandem mass spectrometry and spectra of 375\u20131700\u2009<jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> matched against <jats:italic>T. solium<\/jats:italic> WormBase ParaSite database with MaxQuant software to identify <jats:italic>T. solium<\/jats:italic> proteins. Three hundred and nineteen <jats:italic>T. solium<\/jats:italic> proteins were identified in 87.5% of pNCC and 56.6% of non\u2010NCC subjects. Three hundred and four proteins were exclusive to pNCC sera, seven to non\u2010NCC sera and eight in both. Ten percent, exhibiting immune\u2010modulatory properties, originated from the oncosphere and cyst vesicular fluid. In conclusion, in endemic regions, <jats:italic>T. solium<\/jats:italic> proteins are detected in sera of individuals with and without pNCC. The immunomodulatory nature of these proteins may influence susceptibility and course of infection.<\/jats:p>","DOI":"10.1111\/pim.13058","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T05:05:10Z","timestamp":1722229510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mass Spectrometry Identifies <i>Taenia solium<\/i> Proteins in Sera of Patients With and Without Parenchymal Neurocysticercosis"],"prefix":"10.1111","volume":"46","author":[{"given":"Betcy\u00a0Evangeline","family":"Pamela","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhaya","family":"Patole","sequence":"additional","affiliation":[{"name":"Proteomic Facility National Centre for Biological Sciences  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subashini","family":"Thamizhmaran","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjith\u00a0K.","family":"Moorthy","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephin","family":"Manoj","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupriya","family":"Thanigachalam","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James\u00a0R.\u00a0S.","family":"Hocker","sequence":"additional","affiliation":[{"name":"Laboratory of Carol F. 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