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The 50 mice were divided into control, infected, praziquantel\u2010treated, <jats:italic>M<\/jats:italic>. <jats:italic>oleifera<\/jats:italic> seed oil extract\u2010treated and combined treatment groups. These treatments were examined for their effects on egg granulomas, hepatic enzymes, total protein, albumin, antioxidant enzymes and pro\u2010inflammatory cytokines. <jats:italic>M<\/jats:italic>. <jats:italic>oleifera<\/jats:italic> seed oil and\/or PZQ significantly reduced egg numbers, granuloma size and liver histopathology. <jats:italic>M<\/jats:italic>. <jats:italic>oleifera<\/jats:italic> seed oil reduced hepatic enzyme activity, increased total protein and albumin, and increased antioxidant enzyme activity while decreasing malondialdehyde. <jats:italic>M<\/jats:italic>. <jats:italic>oleifera<\/jats:italic> seed oil reduced the levels of pro\u2010inflammatory cytokines. <jats:italic>M<\/jats:italic>. <jats:italic>oleifera<\/jats:italic> seed oil may treat schistosomiasis instead of PZQ due to its antifibrotic, immunomodulatory and schistosomicidal properties.<\/jats:p>","DOI":"10.1111\/pim.13070","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T12:09:24Z","timestamp":1730722164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Schistosomicidal Effects of <i>Moringa oleifera<\/i> Seed Oil Extract on <i>Schistosoma mansoni<\/i>\u2010Infected Mice"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9297-8326","authenticated-orcid":false,"given":"Alshimaa\u00a0M.","family":"Elmalawany","sequence":"first","affiliation":[{"name":"Clinical Pathology Department National Liver Institute, Menoufia University  Shibin Elkom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamalat\u00a0Y.","family":"Osman","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Menoufia University  Shibin Elkom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza\u00a0H.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Menoufia University  Shibin Elkom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatema\u00a0M.","family":"Khalaf","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Menoufia University  Shibin Elkom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7754-2049","authenticated-orcid":false,"given":"Rania\u00a0I.","family":"Yassien","sequence":"additional","affiliation":[{"name":"Histology Department, Faculty of Medicine Menoufia University  Shibin Elkom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008995"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12111834"},{"key":"e_1_2_8_4_1","unstructured":"WHO \u201cSchistosomiasis \u201dWorld Health Organization (2020) https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/schistosomiasis."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02582\u201016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9060417"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035\u20109203(02)90405\u20100"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249\u2010018\u20100391\u2010x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28196807"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2023.2179454"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12173077"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101\u2010024\u201009927\u2010x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122141"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11233787"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010022\u201023098\u20102"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants13010020"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6627265"},{"key":"e_1_2_8_18_1","first-page":"791","article-title":"Moringa oleifera: A Review of Pharmacological Benefits","volume":"12","author":"Al\u2010Shahat D. 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