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However, the mechanisms accounting for this have not been fully described and in some cases could be argued to reflect the severe neuropathology that some mice suffer during infection. Herein we employ a multi\u2010omics approach to extensively examine BALB\/c mice that are resistant to toxoplasmic encephalitis. Using a combination of LCMS (liquid chromatography\u2013mass spectrometry) and RNAseq we demonstrate that infection alters the neurochemistry and the transcriptome of the brains of BALB\/c mice. Notable changes to tryptophan, purine, arginine, nicotinamide and carnitine metabolism were observed in infected mice and this was accompanied with changes to the levels of a number of transcripts associated with enzymes these metabolic pathways. In addition, changes were seen in transcripts of many immunologically important genes known to contribute to immunity to <jats:italic>T. gondii<\/jats:italic>. Changes in the levels of additional transcripts during infection have previously been associated with psychoneurological diseases. The results demonstrate that the BALB\/c mouse, with its relatively mild neurological disease, is a useful model for characterising the effects of <jats:italic>T. gondii<\/jats:italic> infection on murine neurochemistry. The results also implicate specific biochemical pathways in mediating these changes and should inform further mechanistic studies and suggest therapeutic targets.<\/jats:p>","DOI":"10.1111\/pim.13073","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T08:40:53Z","timestamp":1731314453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Toxoplasma gondii<\/i> Infection of <scp>BALB<\/scp>\/c Mice Perturbs Host Neurochemistry"],"prefix":"10.1111","volume":"46","author":[{"given":"Aisha A.","family":"Abdelati Abdelsalam","sequence":"first","affiliation":[{"name":"Strathclyde Institute of Pharmacy &amp; Biomedical Sciences University of Strathclyde  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Woods","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy &amp; Biomedical Sciences University of Strathclyde 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