{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:58:32Z","timestamp":1791381512227,"version":"4.3.3"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006182","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016136","name":"Fundacion Araucaria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016136","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fasciolosis is a parasitosis of great importance for livestock, as well as for public health, as it is considered by the WHO as a neglected disease. Disease control is complex and reinfections make the use of therapeutic products an unsustainable method from an economic, environmental and health point of view. The aim of this study was to evaluate a new vaccine formulation for dairy cattle, containing soluble\n                    <jats:italic>Fasciola hepatica<\/jats:italic>\n                    antigens associated with Montanide 763 AVG and saponin adjuvants (FhSAMS). The vaccine was tested with two protocols, a single dose and a booster dose 6\u2009months after the first dose. The FhSAMS vaccine proved to be safe, with no side effects. Furthermore, it was able to generate a more robust humoral immune response when a six\u2010month booster dose was used, in addition to stimulating greater production of IFN\u2010\u028f, indicating a Th1 profile immune stimulus.\n                  <\/jats:p>","DOI":"10.1111\/pim.13074","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T09:19:52Z","timestamp":1731057592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and Immunogenicity of an\n                    <scp>FhSAMS<\/scp>\n                    Vaccine Against\n                    <i>Fasciola hepatica<\/i>\n                    in Dairy Cattle"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7806-0519","authenticated-orcid":false,"given":"Kelvinson Fernandes","family":"Viana","sequence":"first","affiliation":[{"name":"Vaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences Federal University of Latin American Integration  Foz do Igua\u00e7u Puerto Rico Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e2nia do Carmo","family":"Sperandio","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Federal University of Esp\u00edrito Santo  Alegre Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-0314","authenticated-orcid":false,"given":"Felipe Berbari","family":"Neto","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Federal University of Esp\u00edrito Santo  Alegre Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirlei Molinari","family":"Donatele","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Federal University of Esp\u00edrito Santo  Alegre Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrieli Barboza","family":"de Souza","sequence":"additional","affiliation":[{"name":"Vaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences Federal University of Latin American Integration  Foz do Igua\u00e7u Puerto Rico Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo Gabriel Vidal","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Vaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences Federal University of Latin American Integration  Foz do Igua\u00e7u Puerto Rico Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u00e7ucena Veleh","family":"Rivas","sequence":"additional","affiliation":[{"name":"Vaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences Federal University of Latin American Integration  Foz do Igua\u00e7u Puerto Rico Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ema Carolina de Almeida","family":"Barcellos","sequence":"additional","affiliation":[{"name":"Vaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences Federal University of Latin American Integration  Foz do Igua\u00e7u Puerto Rico Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Vilhena Freire","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Federal University of Esp\u00edrito Santo  Alegre Esp\u00edrito Santo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtusci.2013.12.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652014000100005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2011.07.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000482"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010800099\u20101.00002\u20108"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Bioclimatic distribution and prevalence maps for Fasciola hepatica in Esp\u00edrito Santo State, Brazil","volume":"20","author":"Freitas D. 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