{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:06:58Z","timestamp":1786482418647,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Fasciola hepatica<\/jats:italic>\n                    <\/jats:styled-content>\n                    is a trematode parasite of significant veterinary and public health importance, causing economic losses in livestock due to liver damage, weight loss and reduced milk production. Although triclabendazole (TCZ) is available for treatment, it does not prevent the disease or reinfection. Infected animals exhibit strong immunoregulation, increasing susceptibility to secondary infections and altering vaccine\u2010induced antibody responses. This study investigates the humoral immune response in cattle infected with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>F. hepatica<\/jats:italic>\n                    <\/jats:styled-content>\n                    at different stages of infection and evaluates the effect of TCZ treatment on this response. It also examines how fasciolosis affects the antibody response induced by bacterial vaccines during early and chronic infection stages. Experimental infections in steers were conducted, with faecal and plasma samples collected at various intervals. The results showed a decrease in parasite\u2010specific antibody avidity during infection. However,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>F. hepatica<\/jats:italic>\n                    <\/jats:styled-content>\n                    infection did not substantially modify antibody response to bacterial vaccines. This study underscores the need for further research on the impact of fasciolosis and its treatment on livestock vaccination efficacy.\n                  <\/jats:p>","DOI":"10.1111\/pim.13079","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T06:32:25Z","timestamp":1733812345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of\n                    <scp>\n                      <i>Fasciola hepatica<\/i>\n                    <\/scp>\n                    Infection and Triclabendazole Treatment on Humoral Immune Response in Cattle"],"prefix":"10.1111","volume":"46","author":[{"given":"Monique","family":"Costa","sequence":"first","affiliation":[{"name":"Laboratorio de Inmunomodulaci\u00f3n y Vacunas Unidad Acad\u00e9mica de Inmunobiolog\u00eda, Facultad de Medicina, Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3624-2437","authenticated-orcid":false,"given":"Anderson","family":"Saravia","sequence":"additional","affiliation":[{"name":"Plataforma de Investigaci\u00f3n en Salud Animal Instituto Nacional de Investigaci\u00f3n Agropecuaria  Colonia Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Ubios","sequence":"additional","affiliation":[{"name":"Programa de Investigaci\u00f3n en Producci\u00f3n de Leche Instituto Nacional de Investigaci\u00f3n Agropecuaria  Colonia Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Paolazzi","sequence":"additional","affiliation":[{"name":"Agropharma Salud Animal S. 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Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Capozzo","sequence":"additional","affiliation":[{"name":"Centro de Altos Estudios en Ciencias Humanas y de la Salud CONICET\u2010Universidad Abierta Interamericana  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7808-8845","authenticated-orcid":false,"given":"Teresa","family":"Freire","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunomodulaci\u00f3n y Vacunas Unidad Acad\u00e9mica de Inmunobiolog\u00eda, Facultad de Medicina, Universidad de la Rep\u00fablica  Montevideo 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