{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:48:08Z","timestamp":1789350488819,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T00:00:00Z","timestamp":1473724800000},"content-version":"vor","delay-in-days":8383,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Helper T cell subset induction was examined within a single inbred strain of mouse ( B10.D2\/n) where individuals varied in their ability to expel the nematode parasite <jats:italic>Trichuris muris<\/jats:italic>. In this mouse strain approximately half of infected individuals resist infection whilst half are unable to expel the parasite and harbour chronic mature adult worm infections. We here assess various T cell and serological parameters in individual B10.D2\/n mice infected with <jats:italic>T. muris<\/jats:italic> in relation to the number of parasites harboured. Worm burdens showed very significant negative correlations with five different parameters indicative of the selective expansion within the host of helper T cells of the Th2 subset. Thus, in vitro IL\u20105 and 1L\u20109 production by restimulated mesenteric lymph node cells, totallgE levels, the early parasite\u2010specific IgG1 response (all P &lt; 0\u00b701) and intestinal eosinophilia (<jats:italic>P<\/jats:italic> &lt; 0\u00b705), were all significantly negatively correlated with worm burden. In addition, levels of IL\u20103 were significantly greater in mice resistant to infection (<jats:italic>P<\/jats:italic> &lt; 0\u00b701). In contrast there was a significant positive correlation between worm burden and parasite\u2010specific IgG2a levels (<jats:italic>P<\/jats:italic> &lt; 0\u00b705), IgG2a production being under the tight control of the Th1\u2010specific cytokine IFN\u2010y and thus a reliable marker for in vivo Th1 cell activation. The data demonstrates that an individual infected with <jats:italic>T. muris<\/jats:italic> is capable of mounting either a protective Th2\u2010type response or an inappropriate Th1\u2010type response. Thus, under conditions where host genetic factors and route of antigen introduction into the host are identical, polarized helper T cell responses can arise and hence may be due to a parasite\u2010derived influence rather than an intrinsic difference between hosts per se.<\/jats:p>","DOI":"10.1111\/pim.1993.15.10.595","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T13:45:39Z","timestamp":1473774339000},"page":"595-600","source":"Crossref","is-referenced-by-count":86,"title":["Correlations between worm burden and markers of Th1 and Th2 cell subset induction in an inbred strain of mouse infected with <i>Trichuris muris<\/i>"],"prefix":"10.1111","volume":"15","author":[{"given":"K.J.","family":"Else","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.M.","family":"Entwistle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.K.","family":"Grencis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,13]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.4049\/jimmunol.145.9.2803","article-title":"Heterogeneity of helper\/inducer T lymphocytes. 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