{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:38:14Z","timestamp":1789148294094,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2023NSCQ\u2010MSX0788"],"award-info":[{"award-number":["CSTB2023NSCQ\u2010MSX0788"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172296"],"award-info":[{"award-number":["82172296"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Frequent recrudescence is responsible for persistent\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    infection after the acute stage. Our previous study demonstrated that phagocytic cells are essential for controlling\n                    <jats:italic>Plasmodium chabaudi chabaudi AS<\/jats:italic>\n                    (\n                    <jats:italic>P. chabaudi<\/jats:italic>\n                    ) recrudescence. Nevertheless, the specific type of phagocytic cells involved in controlling\n                    <jats:italic>P. chabaudi<\/jats:italic>\n                    recrudescence, as well as their underlying molecular mechanisms of action, remain elusive. Herein we employ single\u2010cell RNA sequencing (scRNA\u2010seq) to analyse splenic phagocytic cells during both the acute and recrudescent phases of\n                    <jats:italic>P. chabaudi<\/jats:italic>\n                    infection. Using scRNA\u2010seq, we found that monocyte\u2010derived macrophages (MDMs) declined during the acute stage of\n                    <jats:italic>P. chabaudi<\/jats:italic>\n                    blood\u2010stage infection, and then expanded rapidly in the recrudescence stage. The changing trend of MDMs was confirmed by flow cytometry. To explore the potential role of MDMs in controlling parasitemic recrudescence, MDMs were reduced by a low dose of clodronate liposomes (CLs) during the recrudescence stage, which significantly elevated the\n                    <jats:italic>P. chabaudi<\/jats:italic>\n                    parasitemia. Additionally, no significant difference in the proportion of splenic MDMs or classical monocytes (CMs) within the monocyte population was observed between the infected CCR2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice and their control littermates, suggesting that the transition from CMs to MDMs may not occur in this model. The results indicate that MDMs potentially play a protective role in preventing malarial parasitemic recrudescence, offering valuable insights into immune\u2010based interventions against\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    infection and potentially contributing to the prevention of malaria transmission.\n                  <\/jats:p>","DOI":"10.1111\/pim.70010","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T08:30:45Z","timestamp":1748939445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Potential Role of Monocyte\u2010Derived Macrophages in Preventing Malarial Parasitemic Recrudescence in a Mouse Model"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9951-2414","authenticated-orcid":false,"given":"Jiaqin","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suilin","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Diagnostic Center General Hospital of Xinjiang Military Region  Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongling","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Immunology Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyue","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"},{"name":"Key Laboratory of Extreme Environmental Medicine Ministry of Education of China  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"},{"name":"Key Laboratory of Extreme Environmental Medicine Ministry of Education of China  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"World Health Organization \u201cWorld Malaria Report 2024 \u201d(2024). 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