{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:49Z","timestamp":1772160889683,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871243"],"award-info":[{"award-number":["81871243"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Osteoarthritis (OA), a degenerative condition, severely impacts the quality of life in elderly individuals. Current clinical treatment options for OA remain limited. The polarisation of synovial macrophages plays a pivotal role in OA progression. SJMHE1, a peptide derived from\n                    <jats:italic>Schistosoma japonicum<\/jats:italic>\n                    (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. japonicum<\/jats:italic>\n                    <\/jats:styled-content>\n                    ), has demonstrated the ability to inhibit inflammatory responses such as those seen in asthma and enteritis. Herein, SJMHE1 was administered via intra\u2010articular injection to rats with anterior cruciate ligament transection (ACLT)\u2010induced OA. Its effects on synovial inflammation, cartilage degradation and macrophage polarisation were assessed. Additionally, SJMHE1\u2010stimulated macrophages were co\u2010cultured with chondrocytes to examine chondrocyte degradation and apoptosis. The effect of the peptide on the expression of inflammatory cytokines in peripheral blood mononuclear cells (PBMCs) derived from patients with OA was also evaluated. SJMHE1 treatment delayed OA progression in elderly rats. It inhibited M1 macrophage polarisation, promoted M2 macrophage polarisation, reduced synovial inflammation and alleviated cartilage degradation. In the synovium, SJMHE1 downregulated proinflammatory cytokine IL\u20106 and upregulated the anti\u2010inflammatory cytokine IL\u201010. In\u00a0vitro, SJMHE1\u2010treated macrophages preserved chondrogenic properties and inhibited chondrocyte apoptosis. Furthermore, SJMHE1 suppressed inflammatory cytokine production in PBMCs from patients with OA. The results suggest that SJMHE1 could represent a potential therapeutic approach for managing OA.\n                  <\/jats:p>","DOI":"10.1111\/pim.70018","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T06:45:05Z","timestamp":1755067505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Schistosoma japonicum<\/i>\n                    \u2010Derived Peptide\n                    <scp>SJMHE1<\/scp>\n                    Attenuates Osteoarthritis by Promoting Synovial\n                    <scp>M2<\/scp>\n                    Macrophage Polarisation"],"prefix":"10.1111","volume":"47","author":[{"given":"Wei","family":"Zhu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyun","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Jiangsu University  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang","family":"Wang","sequence":"additional","affiliation":[{"name":"Tzu Chi International College of Traditional Chinese Medicine  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefeng","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Jiangsu University  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhenjiang First People's Hospital  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimin","family":"Fan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06006-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-3681-2_6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1877"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.4.303"},{"issue":"120","key":"e_1_2_10_6_1","first-page":"57","article-title":"Innate Inflammation and Synovial Macrophages in Osteoarthritis Pathophysiology","volume":"37","author":"Griffin T. 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