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This can be mitigated by dietary antioxidants. We investigated the protective effects of lycopene (LYC) against oxidative changes induced by <jats:italic>Plasmodium berghei<\/jats:italic> (Pb). Mice were infected by intraperitoneal injection of 10<jats:sup>6<\/jats:sup> parasitized red blood cells and treated orally with LYC (3.11\u2009mg\/kg bw\/day) or N\u2010acetylcysteine (NAC, 62\u2009mg\/kg bw\/day). Evaluations were conducted at 1\u2010, 4\u2010, 8\u2010 and 12\u2010days post\u2010infection. We measured thiobarbituric acid reactive substances (TBARS), antioxidant capacity by ABTS (AC\u2010ABTS) and DPPH (AC\u2010DPPH) inhibition, uric acid (UA) and nitric oxide (NO) in brain and lung tissues. Infection led to elevated TBARS, AC\u2010ABTS, AC\u2010DPPH, UA and NO, resulting in animal mortality. LYC significantly attenuated the infection\u2010induced increases in TBARS, UA and NO levels compared to Pb (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and NAC\u2009+\u2009Pb groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) normalising them to Sham levels. These findings highlight LYC's therapeutic potential against malaria\u2010related oxidative stress.<\/jats:p>","DOI":"10.1111\/pim.70019","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T07:20:08Z","timestamp":1755933608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lycopene Mitigates Malaria\u2010Induced Reactive Oxygen and Nitrogen Species and Oxidative Damage in Mice Brain and Lungs"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9710-3791","authenticated-orcid":false,"given":"Everton Luiz Pompeu","family":"Varela","sequence":"first","affiliation":[{"name":"Oxidative Stress Research Laboratory, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Postgraduate Program in Biodiversity and Biotechnology \u2013 BIONORTE Network Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 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