{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:46:04Z","timestamp":1791582364932,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Visceral leishmaniasis is a potentially fatal zoonosis with an increasing incidence. Most infected felines present the disease in its subclinical form and demonstrate greater resistance to parasitemia than dogs. However, the role of cellular immunity in felines is still poorly understood. This study measured serum levels of interleukin (IL)\u201012 and interferon\u2010gamma (IFN\u2010\u03b3) in asymptomatic cats naturally infected with antibodies against\n                    <jats:italic>Leishmania<\/jats:italic>\n                    spp. and in uninfected cats. IL\u201012 and IFN\u2010\u03b3 were measured in serum samples by ELISA. Parasite load quantification was performed on DNA from bone marrow samples using qPCR. Cats naturally infected by\n                    <jats:italic>Leishmania spp<\/jats:italic>\n                    . showed significantly higher serum levels of IL\u201012 and IFN\u2010\u03b3 compared to control animals. IL\u201012 showed a positive correlation with IFN\u2010\u03b3 suggesting a regulatory role of IL\u201012 in activating the Th1 immune response, which enhances macrophage function and promotes intracellular parasite elimination. Additionally, IL\u201012 showed a moderate negative correlation with parasite load, indicating a protective effect of IL\u201012 in feline leishmaniasis. These findings suggest that IL\u201012 and IFN\u2010\u03b3 play critical roles in modulating the feline immune response against parasitic infection, possibly contributing to the control of parasite replication and in the prevention of clinical signs. The immune response observed in felines could be explored for future immunotherapeutic approaches, helping to mitigate the progression of leishmaniasis in cats and reducing the risk of transmission in endemic regions.\n                  <\/jats:p>","DOI":"10.1111\/pim.70021","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T06:44:08Z","timestamp":1755067448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>IL<\/scp>\n                    \u201012 and\n                    <scp>IFN<\/scp>\n                    \u2010\u03b3 in Response to\n                    <i>Leishmania Infantum<\/i>\n                    Antigens in Felines From an Endemic Area for Visceral Leishmaniasis"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5868-1257","authenticated-orcid":false,"given":"Jo\u00e3o Victor L\u00e9","family":"Lode","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Surgery and Animal Reproduction S\u00e3o Paulo State University (UNESP), School of Veterinary Medicine  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Takeshi Siqueira","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Surgery and Animal Reproduction S\u00e3o Paulo State University (UNESP), School of Veterinary Medicine  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1154-4693","authenticated-orcid":false,"given":"Gisele Mitsue","family":"Umino","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Surgery and Animal Reproduction S\u00e3o Paulo State University (UNESP), School of Veterinary Medicine  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria Mar\u00e7al Felix","family":"de Lima","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Surgery and Animal Reproduction S\u00e3o Paulo State University (UNESP), School of Veterinary Medicine  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2022.06.012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-015-0909-z"},{"issue":"2","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1590\/s1984-29612023035","article-title":"Feline Leishmaniosis: Hematological and Biochemical Analysis","volume":"32","author":"Silva D. 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