{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:17:36Z","timestamp":1793506656288,"version":"4.5.0"},"reference-count":66,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["022.006.010"],"award-info":[{"award-number":["022.006.010"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015084","name":"Lung Foundation Netherlands","doi-asserted-by":"publisher","award":["5.1.15.015"],"award-info":[{"award-number":["5.1.15.015"]}],"id":[{"id":"10.13039\/501100015084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Schistosome parasites are known to modulate host immune responses, which is achieved in part through the release of excretory\/secretory (ES) products, including extracellular vesicles (EVs). During chronic schistosomiasis, increased regulatory responses are found, which include enhanced IL\u201010 production by B (Breg) cells. ES products from schistosome eggs are able to induce IL\u201010 production by B cells. However, since infection with male worms only (without egg production) also promotes IL\u201010 producing B cells, we here studied the stimulatory effects of adult worm ES and EVs on murine and human B cells. Worm ES increased IL\u201010 release by mouse splenic B cells; this activity was concentrated in defined size\u2010separated fractions of adult worm ES. Interestingly, mass spectrometry of the fractions that induced the highest IL\u201010 response revealed an enrichment of EV\u2010associated proteins. Indeed, highly purified adult worm EVs could interact with mouse splenic B cells, visualised by binding of a schistosome\u2010specific tetraspanin (TSP2) targeting antibody. Furthermore, purified adult worm EVs induced IL\u201010 release in both mouse splenic and human peripheral blood B cells, suggesting that adult worm EVs can play a role in immune regulatory processes within their host.<\/jats:p>","DOI":"10.1111\/pim.70023","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T10:31:14Z","timestamp":1757327474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Extracellular Vesicles From\n                    <i>Schistosoma mansoni<\/i>\n                    Adult Worms Stimulate\n                    <scp>IL<\/scp>\n                    \u201010 Release by B Cells"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7012-3004","authenticated-orcid":false,"given":"Marije E.","family":"Kuipers","sequence":"first","affiliation":[{"name":"Department of Parasitology Leiden University Medical Center  Leiden the Netherlands"},{"name":"Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0613-8372","authenticated-orcid":false,"given":"Arifa","family":"Ozir\u2010Fazalalikhan","sequence":"additional","affiliation":[{"name":"Department of Parasitology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1932-9696","authenticated-orcid":false,"given":"Simone","family":"Haeberlein","sequence":"additional","affiliation":[{"name":"Department of Parasitology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole N.","family":"Driessen","sequence":"additional","affiliation":[{"name":"Department of Parasitology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-0482","authenticated-orcid":false,"given":"Clarize M.","family":"de Korne","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases Leiden University Medical Center  Leiden the Netherlands"},{"name":"Interventional Molecular Imaging Laboratory, Department of Radiology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8807-7795","authenticated-orcid":false,"given":"Lynn","family":"Mes","sequence":"additional","affiliation":[{"name":"Department of Parasitology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3193-5445","authenticated-orcid":false,"given":"Paul J.","family":"Hensbergen","sequence":"additional","affiliation":[{"name":"Center for Proteomics and Metabolomics Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3172-9959","authenticated-orcid":false,"given":"Esther N. 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