{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:51Z","timestamp":1772160891753,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8176120052"],"award-info":[{"award-number":["8176120052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to elucidate how osteopontin (OPN) affects the growth, invasion, and extrahepatic metastasis of\n                    <jats:italic>Echinococcus multilocularis<\/jats:italic>\n                    (\n                    <jats:italic>Em<\/jats:italic>\n                    ) through the p38MAPK signalling pathway of host hepatocytes. C57BL\/6J mice were randomly divided into the control group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910), the LV\u2010OPN\u20100423 group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910), the anti\u2010p38MAPK group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910), and the anti\u2010p38MAPK\u2009+\u2009LV\u2010OPN\u20100423 group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910).\n                    <jats:italic>Em<\/jats:italic>\n                    infection models in mice were set up. The mice were fed for 6\u2009weeks under suitable conditions. The mice in the anti\u2010p38MAPK group and the anti\u2010p38MAPK\u2009+\u2009LV\u2010OPN\u20100423 group were then given SB202190 (this is an inhibitor of p38MAPK) for 4\u2009weeks, and the mice in each group were injected with corresponding lentivirus diluent once a week for 8\u2009weeks. After the intervention was completed, the liver volume and weight were measured, and the liver was embedded in paraffin and sectioned. Sections were subjected to haematoxylin and eosin (HE), periodic acid\u2010Schiff (PAS), and immunohistochemical staining to observe the growth and invasion of\n                    <jats:italic>Em<\/jats:italic>\n                    , as well as the expression levels of OPN, p38MAPK, and p\u2010p38MAPK of the host. SB202190 hindered\n                    <jats:italic>Em<\/jats:italic>\n                    's growth, invasion, and migration. The level of OPN facilitated\n                    <jats:italic>Em<\/jats:italic>\n                    's growth, invasion, and migration, which can be reversed by SB202190. The OPN level promoted the expression of p38MAPK and p\u2010p38MAPK. These results suggested that OPN could regulate\n                    <jats:italic>Em<\/jats:italic>\n                    's growth and metastasis through the p38MAPK signalling pathway in host hepatocytes, providing evidence that OPN and p38MAPK may be novel molecular targets for treating alveolar echinococcosis.\n                  <\/jats:p>","DOI":"10.1111\/pim.70041","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T10:11:32Z","timestamp":1763374292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Osteopontin Promotes Liver\n                    <i>Echinococcus multilocularis<\/i>\n                    Growth and Invasion via\n                    <scp>p38MAPK<\/scp>\n                    Pathway"],"prefix":"10.1111","volume":"47","author":[{"given":"Gang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of General Surgery, Qingdao Central Hospital University of Health and Rehabilitation Sciences\uff08Qingdao Central Hospital)  Qingdao Shandong People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Mao","sequence":"additional","affiliation":[{"name":"Qingdao University  Qingdao Shandong People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Qingdao Central Hospital University of Health and Rehabilitation Sciences\uff08Qingdao Central Hospital)  Qingdao Shandong People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"You","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Qingdao Central Hospital University of Health and Rehabilitation Sciences\uff08Qingdao Central Hospital)  Qingdao Shandong People's Republic of 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