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Migrating larvae through the host trigger tissue disruption\/damage, leading to the release of damage\u2010associated molecular patterns (DAMPs). In addition, helminth larvae and adults release excretory\/secretory factors, including proteins, lipids, nucleic acids or carry bacterial symbionts, that act as pathogen\u2010associated molecular patterns (PAMPs), which similar to DAMPs, are sensed by innate receptors [pattern recognition receptors (PRRs), and G protein\u2010coupled receptors (GPCRs) and others] in the skin, liver, lungs, intestines, brain, or smooth muscles, triggering localised innate inflammatory responses. The host's innate immunity plays a central role in controlling the infection and\/or inducing pathogenesis. This review provides a comprehensive examination of how innate immune receptors and their host\u2010 or helminth\u2010derived ligands regulate the control and immunopathogenesis of helminth infections, thereby advancing our understanding of the early host signalling pathways and parasite\u2010derived factors that initiate innate immune responses.<\/jats:p>","DOI":"10.1111\/pim.70042","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T05:53:49Z","timestamp":1765259629000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Innate Immune Recognition of Helminths:\n                    <scp>TLRs<\/scp>\n                    and Beyond"],"prefix":"10.1111","volume":"47","author":[{"given":"Camila","family":"de Almeida Lopes","sequence":"first","affiliation":[{"name":"Laboratory of Innate Immunity and Microbial Pathogenesis, Department of Cellular and Molecular Biology University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-6176","authenticated-orcid":false,"given":"Linda Djune","family":"Yemeli","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Yaound\u00e9 I  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-2206","authenticated-orcid":false,"given":"Pedro","family":"Gazzinelli\u2010Guimaraes","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Tropical Medicine George Washington School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","unstructured":"P. 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