{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:08:00Z","timestamp":1789765680132,"version":"4.0.1"},"reference-count":126,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Leishmania amazonensis<\/jats:italic>\n                    is one of the etiological agents of cutaneous leishmaniasis in its localised form. Moreover, this parasite can cause more severe disease conditions, such as diffuse and disseminated cutaneous leishmaniasis. The development of more severe clinical manifestations is associated with the parasite's ability to establish a chronic infection and disseminate to cutaneous tissues distal to the site of primary infection. This ability is dependent on host immune factors but is also influenced by intrinsic factors of the parasite related to pathogenicity and evasion of the immune system. This review discusses immunological and parasitological factors associated with the latency and dissemination of\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>amazonensis<\/jats:italic>\n                    infection and the consequent development of severe forms of cutaneous disease.\n                  <\/jats:p>","DOI":"10.1111\/pim.70044","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:44:12Z","timestamp":1767843852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanisms of Immune Evasion, Dissemination, and Persistence in\n                    <i>Leishmania amazonensis<\/i>\n                    Infection"],"prefix":"10.1111","volume":"48","author":[{"given":"Arieli Bernardo","family":"Portugal","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunoparasitologia, Instituto de Ci\u00eancias M\u00e9dicas, Universidade Federal do Rio de Janeiro  Maca\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Augusto","family":"DaMatta","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Celular e Tecidual, Universidade Estadual Norte Fluminense (UENF), Campos dos Goytacazes  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed\u00e9zio Ferreira","family":"da Cunha J\u00fanior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunoparasitologia, Instituto de Ci\u00eancias M\u00e9dicas, Universidade Federal do Rio de Janeiro  Maca\u00e9 Brazil"},{"name":"Instituto de Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Rio de Janeiro  Maca\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9707-6284","authenticated-orcid":false,"given":"Jo\u00e3o Luiz Mendes","family":"Wanderley","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunoparasitologia, Instituto de Ci\u00eancias M\u00e9dicas, Universidade Federal do Rio de Janeiro  Maca\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004349"},{"key":"e_1_2_11_3_1","first-page":"575","article-title":"Global Leishmaniasis Surveillance: 2021, Assessing the Impact of the COVID\u201019 Pandemic","volume":"97","author":"Ruiz\u2010Postigo J. A.","year":"2022","journal-title":"Weekly Epidemiological Record"},{"key":"e_1_2_11_4_1","unstructured":"WHO Expert Committee on the Control of the Leishmaniasis \u201cReport of a Meeting of the WHO Expert Commitee on the Control of Leishmaniases Geneva 22\u201026 March 2010. WHO Technical Report Series \u201dWorld Health Organization 949: 1\u2013186 (2010)."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.12.2121"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.226183"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004929"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00860"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2009.11.006"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12020246"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113195"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010019\u20100323\u20108"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trz037"},{"key":"e_1_2_11_14_1","first-page":"189","volume-title":"Manual de vigil\u00e2ncia da leishmaniose tegumentar","author":"Brazil, Minist\u00e9rio da Sa\u00fade","year":"2017"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1415\u2010790X2004000300010"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2019.02.016"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2009.12.008"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2018.06.023"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037\u20108682\u20100377\u20102016"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1984\u201029612016071"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40804"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2005.06.025"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1991.44.536"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000980"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.14670\/HH\u201011\u2010965"},{"issue":"3","key":"e_1_2_11_26_1","first-page":"16","article-title":"Leishmaniose cut\u00e2nea difusa (LCD) no Brasil ap\u00f3s 60 anos de sua primeira descri\u00e7\u00e3o","volume":"79","author":"Costa J. M. L.","year":"2009","journal-title":"Diffuse Cutaneous Leishmaniasis (DCL)"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20103024.2009.01116.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41182\u2010016\u20100002\u20100"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806\u20104841.20198775"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.7.2952-2959.1993"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00058"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035\u20109203(91)90437\u20104"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2021.106018"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074\u201002762011000100004"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.8.4278\u20104288.2003"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.72"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761992000200010"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1636090"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.13.040195.001055"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri933"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11880"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226837"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12722"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2019.06.003"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2004.06.003"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9061268"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0307187"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02103\u201005"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu455"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0074\u201002762004000300001"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194383"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007152"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102567.2009.03134.x"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2004.06.003"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.9.1603"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1471\u20104922(01)01895\u20105"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166\u20106851(93)90095\u2010f"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1006\/sceL.1993.1038"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014\u20104894(03)00135\u20108"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004848"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12020173"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074\u201002760200140"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.03.004"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182013002187"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/dst031"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112410"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0020\u20107519(01)00197\u20107"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109072200"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271492"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.35.21583"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1286\u20104579(99)80058\u20106"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830271028"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0169\u20104758(00)01791\u20109"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182007002569"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430\u2010004\u20100229\u2010y"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.2147\/HIV.S93789"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469\u20100691.12556"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0031182097001789"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12862"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102334\u201014\u2010450"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12668"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413\u201086702010000500009"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20104632.2012.05709.x"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003411"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037\u201086822001000600013"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1159194"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.598943"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12674"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunoL.173.11.6521"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188083"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900226106"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunoL.0903273"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00770\u201013"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/0\u2010306\u201046831\u2010X_14"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324586"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12019"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830230730"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0074\u201002761997000300006"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20109292\u20106\u20105"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035\u20109203(74)90148\u20105"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/0001\u2010706x(94)90103\u20101"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20\u20100131"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.824494"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.10.1497"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunoL.165.2.969"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035\u20109203(92)90297\u2010p"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190\u20109622(93)70132\u2010d"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1996.0104"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1985.34.850"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540505300105"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080905"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026\u2010014\u20108535\u2010y"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.11"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3469"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u20106968.2006.00495.x"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2009.03.041"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.09.114"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010019\u20100482\u20108"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960\u20109822(01)00563\u20102"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005733"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunoL.176.3.1834"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00403"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001469"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1017\/s003118200008183x"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002179"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.8.5606"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12596"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.70044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pim.70044","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.70044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:29:06Z","timestamp":1769495346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.70044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":126,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/pim.70044"],"URL":"https:\/\/doi.org\/10.1111\/pim.70044","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PIM.70044\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70044"}}