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While host immunity is central to parasite clearance, diet and the gut microbiota may also modulate infection. Using the\n                    <jats:italic>Trichuris muris<\/jats:italic>\n                    model, we examined how immune competence and diet interact to influence worm burden, antibody responses, and gut microbiota composition. Wild\u2010type (WT), RAG1\u2010deficient (lacking adaptive immunity), and RAG1\/\n                    <jats:italic>\u03b3<\/jats:italic>\n                    c\u2010deficient (lacking both adaptive and innate lymphoid immunity) mice were fed either a normal diet (ND) or high\u2010fat diet (HFD) and infected with a low dose of\n                    <jats:italic>T. muris<\/jats:italic>\n                    . WT mice on ND developed chronic infection with strong IgG2a\/c responses, consistent with Th1\u2010biased immunity. In contrast, WT mice on HFD achieved near\u2010complete parasite clearance, accompanied by elevated IgG1 and reduced IgG2a\/c titres, indicating diet\u2010induced Th2 bias. In RAG1\u2010 and RAG1\/\n                    <jats:italic>\u03b3<\/jats:italic>\n                    c\u2010deficient mice, infection persisted under a normal diet but worm burdens were partially reduced on HFD, indicating that diet enhances parasite control through immune\u2010independent, possibly microbiota\u2010mediated pathways. Microbiota clustered by genotype and diet, with HFD\u2010associated enrichment of\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    ,\n                    <jats:italic>Parabacteroides<\/jats:italic>\n                    , and\n                    <jats:italic>Blautia<\/jats:italic>\n                    . These findings demonstrate that diet and immune status jointly shape helminth susceptibility through coordinated effects on host immunity and the gut microbiota.\n                  <\/jats:p>","DOI":"10.1111\/pim.70060","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T05:30:47Z","timestamp":1770096647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Influence of Innate Immunity, Adaptive Immunity and Diet on Intestinal Microbiota Following\n                    <scp>\n                      <i>Trichuris muris<\/i>\n                    <\/scp>\n                    Infection"],"prefix":"10.1111","volume":"48","author":[{"given":"Bridgious","family":"Walusimbi","sequence":"first","affiliation":[{"name":"Immunomodulation and Vaccines Group, Vaccine Research Theme, Medical Research Council Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC\/UVRI &amp; LSHTM) Uganda Research Unit  Entebbe Uganda"},{"name":"Department of Immunology &amp; Molecular Biology School of Biomedical Science, College of Health Sciences, Makerere University  Kampala Uganda"},{"name":"Department of Clinical Research London School of Hygiene and Tropical Medicine  London UK"},{"name":"Faculty of Biology Medicine and Health, University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly S.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Faculty of Biology Medicine and Health, University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa A. 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