{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:30:25Z","timestamp":1777984225787,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cystic echinococcosis (CE) is a highly common zoonosis worldwide and Tunisia remains the most endemic country in North Africa. The variability of clinical manifestations of CE depends on predisposing factors related to the interaction between host genetic and immunological factors. This study investigates the association between single nucleotide polymorphism (SNP) of IL\u20101\u03b2 (rs16944 and rs1143634), an important pro\u2010inflammatory cytokine in the CE immune response and susceptibility to CE in a Tunisian population. The case group included 152 paediatric patients diagnosed with CE, whereas the control group included 152 healthy individuals. The DNA was extracted via the salting\u2010out method and genotyped via polymerase chain reaction restriction fragment length polymorphism (PCR\u2013RFLP). The \u2212511C\/T genotype is more frequent in the control group than in patients (OR\u2009=\u20090,57,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03, CI\u2009=\u20090.3418\u20130.96). The haplotype \u2212511C\/+3954T was higher in the case group compared to the control group (OR\u2009=\u20092.6,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.00011, CI\u2009=\u20091.62\u20134.31). The SNP \u2212511C\/T in\n                    <jats:italic>IL\u20101\u03b2<\/jats:italic>\n                    gene was associated with CE protection in our paediatric population. The haplotype \u2212511C\/+3954T might be considered as the influential factor for resistance to the disease.\n                  <\/jats:p>","DOI":"10.1111\/pim.70064","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T02:57:22Z","timestamp":1770173842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study of\n                    <i>Interleukin 1\u03b2<\/i>\n                    Gene Polymorphisms in Tunisian Paediatric Population With Cystic Echinococcosis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2603-7495","authenticated-orcid":false,"given":"Amira","family":"Rjibi","sequence":"first","affiliation":[{"name":"Department of Clinical Biology B Faculty of Pharmacy Monastir Tunisia, Laboratory of Medical and Molecular Parasitology  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eya Ben","family":"Salah","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology B Faculty of Pharmacy Monastir Tunisia, Laboratory of Medical and Molecular Parasitology  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Mosbahi","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department Fattouma Bourguiba Hospital, Monastir, Medical School  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh","family":"Belgacem","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology B Faculty of Pharmacy Monastir Tunisia, Laboratory of Medical and Molecular Parasitology  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amine","family":"Ksiaa","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department Fattouma Bourguiba Hospital, Monastir, Medical School  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mongi","family":"Mekki","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department Fattouma Bourguiba Hospital, Monastir, Medical School  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lasaad","family":"Sahnoun","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department Fattouma Bourguiba Hospital, Monastir, Medical School  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamouda","family":"Babba","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology B Faculty of Pharmacy Monastir Tunisia, Laboratory of Medical and Molecular Parasitology  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wahiba","family":"Sakly","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology B Faculty of Pharmacy Monastir Tunisia, Laboratory of Medical and Molecular Parasitology  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apar.2016.07.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed9020036"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"43","article-title":"Distribution of Surgical Hydatidosis in Tunisia, Results of 2001\u20132005 Study and Trends Between 1977 and 2005","volume":"87","author":"Chahed M. 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