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This study evaluated the effects of alternate\u2010day fasting (ADF), high\u2010sucrose diet (HSD) and praziquantel (PZQ) treatment on feeding motivation, anxiety\u2010like behaviour and lung pathology in infected BALB\/c mice. Infected animals received a standard diet (INF), or PZQ (300\u2009mg\/kg for 3\u2009days), ADF, ADF\u2009+\u2009PZQ, HSD or HSD\u2009+\u2009PZQ. After 15\u2009weeks of infection, behavioural parameters, parasite egg load, inflammatory infiltrate, macrophage accumulation and lung structure were analysed. Uninfected was used as control (Wild Type). ADF impaired motor and feeding\u2010related behaviours compared to other groups. Infected mice under a standard diet or ADF showed higher egg deposition and larger pulmonary granulomas than HSD or PZQ\u2010treated animals. Inflammatory infiltrate and alveolar collapse were more intense in INF and ADF groups, while macrophage accumulation increased with ADF but decreased after PZQ. Pulmonary fibrosis was reduced in ADF, HSD and PZQ groups compared to INF, though higher in ADF than in HSD or PZQ. Overall, ADF worsened lung pathology, promoting egg accumulation, granulomatous inflammation, fibrosis and alveolar collapse. These findings suggest that caloric restriction through ADF aggravates pulmonary disease in schistosomiasis, possibly by enhancing ectopic egg dissemination.\n                  <\/jats:p>","DOI":"10.1111\/pim.70068","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T11:44:19Z","timestamp":1771587859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alternate\u2010Day Fasting Exacerbates Lung Inflammatory Disease Compared to High\u2010Sucrose Diet in Experimental Schistosomiasis Mansoni"],"prefix":"10.1111","volume":"48","author":[{"given":"Victoria Nascimento Guimar\u00e3es","family":"Mattar","sequence":"first","affiliation":[{"name":"Department of Structural Biology Federal University of Alfenas (UNIFAL\u2010MG)  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele Oliveira","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Natural Sciences Institute Federal University of Alfenas (UNIFAL\u2010MG)  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7280-9794","authenticated-orcid":false,"given":"La\u00eds de Castro Carvalho","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Structural Biology Federal University of Alfenas (UNIFAL\u2010MG)  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds Gustavo Argero Corbera Noles","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Structural Biology Federal University of Alfenas (UNIFAL\u2010MG)  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara Kramer Chiomark","family":"Malaquias","sequence":"additional","affiliation":[{"name":"Department of Structural Biology Federal University of Alfenas (UNIFAL\u2010MG)  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Rizo","family":"Ventura","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences Federal University of Alfenas (UNIFAL\u2010MG)  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2937-3890","authenticated-orcid":false,"given":"T\u00falio de Almeida","family":"Hermes","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Institute of Biomedical Sciences Federal University of Alfenas (UNIFAL\u2010MG)  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00f4mulo D.","family":"Novaes","sequence":"additional","affiliation":[{"name":"Department of Structural Biology Federal University of Alfenas (UNIFAL\u2010MG)  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Jos\u00e9","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Pathology and Parasitology Federal University of Alfenas (UNIFAL\u2010MG)  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1572-2581","authenticated-orcid":false,"given":"Luis Felipe Cunha","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Department of Structural Biology Federal University of Alfenas (UNIFAL\u2010MG)  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)02814\u20109"},{"key":"e_1_2_11_3_1","first-page":"1","article-title":"Forecasting the Potential Distribution and Niche of Two Similar Gastropod Species in South America: The Intermediate Host of Schistosomiasis Biomphalaria Glabrata and the Invasive Melanoides Tuberculata","volume":"852","author":"Ribas L. 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