{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:30:25Z","timestamp":1777984225796,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Chronic spontaneous urticaria (CSU) is a mast cell driven multifactorial disorder with complex pathogenesis. While the association between CSU and internal parasites has been investigated, the association of ectoparasites such as Demodex mites remains elusive. This study aims to compare Demodex prevalence in CSU patients with healthy controls and to evaluate selected immunologic parameters in Demodex patients. A prospective case\u2013control study was conducted including 100 patients with CSU and 50 age\u2010 and sex\u2010matched controls. Skin surface biopsy was performed using the cyanoacrylate method, and participants were classified as Demodex\u2010positive if more than five mites were detected within a 1\u2009cm\n 2<\/jats:sup>\n field. Serum levels of total IgE, eosinophil counts, thyroid\u2010stimulating hormone (TSH), free thyroxine (T4), and anti\u2010thyroid peroxidase (anti\u2010TPO) antibodies were measured. Demodex positivity was observed in 26% of CSU patients and 26% of controls (\n p<\/jats:italic>\n \u2009=\u20091.00). Median IgE (208.08\u2009IU\/mL, range 4.89\u20131207.00) and eosinophil counts (0.17\u2009\u00b1\u20090.07\u2009\u00d7\u200910\n 9<\/jats:sup>\n \/L) were significantly higher in Demodex\u2010positive participants than in Demodex\u2010negative ones (65.72\u2009IU\/mL, range 2.40\u2013632.11, and 0.14\u2009\u00b1\u20090.09\u2009\u00d7\u200910\n 9<\/jats:sup>\n \/L, respectively;\n p<\/jats:italic>\n \u2009<\u20090.05). Thyroid function parameters and antibody levels showed no significant differences between groups. Although Demodex prevalence did not significantly differ between CSU patients and controls, infestation was associated with elevated IgE and eosinophil levels, suggesting a possible association with type 2\u2013skewed immune markers. Further studies with quantitative mite assessment and detailed immunologic profiling are needed to better understand this relationship.\n <\/jats:p>","DOI":"10.1111\/pim.70073","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:30:28Z","timestamp":1773804628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Demodex in Chronic Urticaria: Lack of Association but Evidence for Type\u20102 Immune Activation in Demodex"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4761-965X","authenticated-orcid":false,"given":"Burak","family":"Celik","sequence":"first","affiliation":[{"name":"Department of Dermatology Ankara City Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5188-1245","authenticated-orcid":false,"given":"Merve","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ankara City Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Emre","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ankara City Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13397"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00389-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14037"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2020.1829593"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12818"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S440199"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1971.tb06853.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usaa040"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000540155"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.70016"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.46497\/ArchRheumatol.2020.7699"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jme\/tjy225"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01173.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000249558"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2011.26.9.1231"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13636"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00964.x"},{"issue":"3","key":"e_1_2_10_20_1","first-page":"899","article-title":"A Study on Demodex Folliculorum Mite Density and Immune Response in Patients With Facial Dermatoses","volume":"35","author":"El\u2010Bassiouni S. O.","year":"2005","journal-title":"Journal of the Egyptian Society of Parasitology"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.21-0853"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.08.001"},{"issue":"1","key":"e_1_2_10_23_1","first-page":"S182","article-title":"Development of Demodicosis After Omalizumab Injection","volume":"35","author":"Park S.","year":"2023","journal-title":"Annals of Dermatology"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.70073","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pim.70073","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.70073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:56:11Z","timestamp":1774565771000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.70073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/pim.70073"],"URL":"https:\/\/doi.org\/10.1111\/pim.70073","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PIM.70073\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70073"}}