{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T11:03:16Z","timestamp":1779706996387,"version":"3.53.1"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Ascaris<\/jats:italic>\n                    infection\u2014ascariasis\u2014is the most common human parasitic worm infection worldwide and induces damage and cellular changes within the stomach.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    is a bacterium of the stomach that also causes gastric pathologies globally. Importantly,\n                    <jats:italic>\n                      Ascaris,\n                      <jats:styled-content style=\"fixed-case\">H. pylori<\/jats:styled-content>\n                      ,\n                    <\/jats:italic>\n                    and gastric diseases all disproportionately\u00a0affect individuals in resource\u2010limited settings. However, the associations between ascariasis,\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection, and gastric diseases remain relatively unexplored.\u00a0We synthesized the existing research associating\n                    <jats:italic>Ascaris<\/jats:italic>\n                    infection with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    infection and\/or gastric pathologies. Records were identified in OVID Medline, Embase and Web of Science using search terms for ascariasis,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    infection, and gastric abnormalities and additional citation searching. Blinded screening and extraction were performed by two independent reviewers. We found 410 unique citations, of which 86 (21.0%) were included. A total of 24 articles (27.9%) associated ascariasis with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    infection, 68 (79.1%) associated ascariasis with gastric abnormalities, and 6 (7.0%) associated ascariasis with both\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    infection and gastric abnormalities. Although predominantly comprised of case reports and observational studies, these data supported significant co\u2010endemicity of ascariasis and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    infection, co\u2010infections with both pathogens, and concurrency of ascariasis with gastric pathologies in human and non\u2010human host organisms. The available literature thus supports associations between ascariasis,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    infections, and gastric pathology, warranting further epidemiologic and mechanistic studies.\n                  <\/jats:p>","DOI":"10.1111\/pim.70080","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:37:02Z","timestamp":1778495822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Scoping Review of the Associations Between Ascariasis,\n                    <scp>\n                      <i>Helicobacter pylori<\/i>\n                    <\/scp>\n                    Infection and Gastric Pathologies"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8336-1471","authenticated-orcid":false,"given":"Nina L.","family":"Tang","sequence":"first","affiliation":[{"name":"Departments of Pediatrics, Division of Pediatric Tropical Medicine, and Molecular Virology and Microbiology, Texas Children's Hospital Center for Vaccine Development, National School of Tropical Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob J.","family":"Williams","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Division of Pediatric Tropical Medicine, and Molecular Virology and Microbiology, Texas Children's Hospital Center for Vaccine Development, National School of Tropical Medicine Baylor College of Medicine  Houston Texas USA"},{"name":"Rice University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Stockton","sequence":"additional","affiliation":[{"name":"Texas Medical Center Library  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8429-0476","authenticated-orcid":false,"given":"Maria Elena","family":"Bottazzi","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Division of Pediatric Tropical Medicine, and Molecular Virology and Microbiology, Texas Children's Hospital Center for Vaccine Development, National School of Tropical Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill E.","family":"Weatherhead","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Division of Pediatric Tropical Medicine, and Molecular Virology and Microbiology, Texas Children's Hospital Center for Vaccine Development, National School of Tropical Medicine Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249\u2010022\u201001038\u2010z"},{"key":"e_1_2_8_3_1","unstructured":"Centers for Disease Control and Prevention Ascariasis DPDx(2025). accessed December 23 2025."},{"key":"e_1_2_8_4_1","unstructured":"World Health Organization Neglected Tropical Diseases GLOBAL(2025). accessed December 23 2025."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.09.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u20100171\u20103"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082795"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010050"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00533\u201018"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2023.106483"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2018.04.015"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0031182000006491"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003877"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(91)90242-Q"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(97)90384-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011930"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0013141"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.036"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.lab.0000085190.99749.15"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1022564027468"},{"key":"e_1_2_8_21_1","first-page":"639","article-title":"Identification of a Metaplastic Cell Lineage Associated With Human Gastric Adenocarcinoma","volume":"79","author":"Schmidt P. H.","year":"1999","journal-title":"Laboratory Investigation"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1017920220149"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i16.3714"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.02.008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26869"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029\u2010020\u201000564\u2010z"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v8.i1.40"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(19)30488\u20107"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14561"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523\u20105378.2011.00916.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2025.103032"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104\u2010018\u20103246\u20104"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2024.102896"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664\u2010020\u201001023\u20100"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2222\u20101808(15)60939\u20102"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12639\u2010021\u201001370\u20105"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102007\u20101021468"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102007\u20101005619"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/512607"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103468(03)00584\u20100"},{"key":"e_1_2_8_43_1","first-page":"377","article-title":"A Roentgenographic Study of Intestinal Ascariasis: With a Report of 3 Cases of Intestinal Obstruction Caused by Ascaris Worms","volume":"17","author":"Balikian J. P.","year":"1964","journal-title":"Journal Medical Libanais"},{"key":"e_1_2_8_44_1","first-page":"117","article-title":"Non Obstetric Causes and Presentation of Acute Abdomen Among the Pregnant Women","volume":"8","author":"Haque M.","year":"2014","journal-title":"Journal of Family & Reproductive Health"},{"key":"e_1_2_8_45_1","first-page":"29","article-title":"Barium Meal Examination in Children an Analysis of 202 Examinations","volume":"12","author":"Chawla S.","year":"1964","journal-title":"Journal of the Association of Physicians of India"},{"key":"e_1_2_8_46_1","first-page":"101","article-title":"Oesophageal Replacement in Paediatric Patients","volume":"37","author":"Aghaji M. A.","year":"1992","journal-title":"Journal of the Royal College of Surgeons of Edinburgh"},{"key":"e_1_2_8_47_1","first-page":"932","article-title":"Ascariasis of the Alimentary Tract, Liver, Pancreas and Biliary System: Its Diagnosis by Ultrasonography","volume":"45","author":"Ferreyra N. P.","year":"1998","journal-title":"Hepato\u2010Gastroenterology"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.2478\/s11687\u2010010\u20100032\u20109"},{"key":"e_1_2_8_49_1","first-page":"433","article-title":"A Comparative Study of Oral and Parenteral Diethylcarbamazine Citrate in the Treatment of Ascariasis","volume":"41","author":"Chari M. V.","year":"1963","journal-title":"Journal of the Indian Medical Association"},{"key":"e_1_2_8_50_1","first-page":"215","article-title":"Clinical Observation on 110 Cases of Ascaris Invasion of the Biliary Tract","volume":"24","author":"Hsu F. H.","year":"1962","journal-title":"Nagoya Journal of Medical Science"},{"key":"e_1_2_8_51_1","first-page":"6","article-title":"Ascariasis and Peptic Ulcer in Radiology","volume":"65","author":"Huque K. S.","year":"1962","journal-title":"Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.14303\/jmms.2013.120"},{"key":"e_1_2_8_53_1","first-page":"37","article-title":"Intestinal Ascariasis in the Differential Diagnosis of Peptic Ulcer Disease","volume":"42","author":"Hamed A. D.","year":"1990","journal-title":"Tropical and Geographical Medicine"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436\u2010021\u201007370\u2010x"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.136.5.121"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.2307\/3277198"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)33291-3"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20104017(76)90063\u20107"},{"key":"e_1_2_8_59_1","article-title":"Inhibitory Effects of Ascaris Suum Extract on Gastric Acid Secretion in Rats","volume":"7","author":"Nwankwoala R. N. P.","year":"2009","journal-title":"Internet Journal of Pharmacology"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.4.1323\u20101327.2001"},{"key":"e_1_2_8_61_1","first-page":"923","article-title":"Expression of Cytokines and Monosaccharide Transporters in the Duodenal Mucosa of Patients With Gastrointestinal Symptoms in Rural Thailand","volume":"36","author":"Lertanekawattana S.","year":"2005","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.Epi\u201005\u20100095"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4927964"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1636768"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1282176"}],"container-title":["Parasite Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.70080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pim.70080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pim.70080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:21:40Z","timestamp":1779704500000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pim.70080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/pim.70080"],"URL":"https:\/\/doi.org\/10.1111\/pim.70080","archive":["Portico"],"relation":{},"ISSN":["0141-9838","1365-3024"],"issn-type":[{"value":"0141-9838","type":"print"},{"value":"1365-3024","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70080"}}