{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:47:02Z","timestamp":1782312422040,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172296"],"award-info":[{"award-number":["82172296"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2025NSCQ\u2010GPX1358"],"award-info":[{"award-number":["CSTB2025NSCQ\u2010GPX1358"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T helper (Th)1 cells are theorized to control\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    parasite burden during blood\u2010stage malaria. However, their exact role in controlling parasitemia in\u00a0vivo remains inadequately characterized. Here, we used a CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010restricted Cre\u2010Lox T\u2010bet (the master regulator of Th1 cells) excision mouse model to examine the role of\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    \u2010specific Th1 cell responses in controlling blood\u2010stage infection. Our results found that T\u2010bet deficiency in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells markedly enhanced the growth of blood\u2010stage\n                    <jats:italic>Plasmodium yoelii<\/jats:italic>\n                    (\n                    <jats:italic>P. yoelii<\/jats:italic>\n                    ) 17XNL and\n                    <jats:italic>Plasmodium chabaudi<\/jats:italic>\n                    (\n                    <jats:italic>P. chabaudi<\/jats:italic>\n                    ) AS, but not\n                    <jats:italic>Plasmodium berghei<\/jats:italic>\n                    (\n                    <jats:italic>P. berghei<\/jats:italic>\n                    ) ANKA. Although T\u2010bet deficiency in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells did not significantly impair the generation of pathogen\u2010specific GC\u2010Tfh cells, GC B cells, or the production of\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    \u2010specific antibodies, it profoundly suppressed\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    \u2010specific Th1 differentiation and IFN\u2010\u03b3 production. Conversely, T\u2010bet deficiency selectively promoted\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    \u2010specific Th17 differentiation without affecting other Th subsets. However, despite the heightened Th17 cell responses, in\u00a0vivo neutralization of IL\u201017A did not impact host defence against\n                    <jats:italic>P. yoelii<\/jats:italic>\n                    17XNL infection. Collectively, our data demonstrate that T\u2010bet in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells enhances\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    \u2010specific Th1 cell responses while restraining\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    \u2010specific Th17 cell differentiation. In addition,\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    \u2010specific Th1 cells can confer substantial protection against blood\u2010stage malaria. These findings support the development of effective malaria vaccines designed to elicit robust CD4\n                    <jats:sup>+<\/jats:sup>\n                    Th1 responses.\n                  <\/jats:p>","DOI":"10.1111\/pim.70090","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:15:09Z","timestamp":1782206109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["T\u2010Bet Modulates\n                    <i>Plasmodium<\/i>\n                    \u2010Specific\n                    <scp>CD4<\/scp>\n                    <sup>+<\/sup>\n                    T Cell Differentiation and Anti\u2010Malarial Immunity During Blood\u2010Stage Infection"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8251-5037","authenticated-orcid":false,"given":"Hangyu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongling","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nie","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyue","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"},{"name":"Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology Army Medical University (Third Military Medical University)  Chongqing China"},{"name":"Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02246-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.30875\/9789287074560"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01099-x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01065-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0117-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008840"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0158-z"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.844975"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aal2192"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.012"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08528-z"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009871"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn5993"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074627"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-12-108"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31640-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.143.6.2038"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1997.d01-187.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.8.4399-4406.2000"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.07.003"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-020-0196-3"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39222"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201190"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2200899"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-061020-053702"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80702-3"},{"issue":"12","key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/dvg.22052","article-title":"Generation 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