{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:02:07Z","timestamp":1790161327876,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011597","name":"Conselleria de Sanitat Universal i Salut P\u00fablica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011597","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Parasite Immunology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Parasitic infections can induce immunomodulatory effects that may influence host responses to vaccination. Chronic exposure to\n                    <jats:italic>Anisakis<\/jats:italic>\n                    antigens could modify T\u2010cell and antibody profiles, potentially affecting SARS\u2010CoV\u20102 vaccine effectiveness in endemic populations. We aimed to determine whether prior exposure to\n                    <jats:italic>Anisakis<\/jats:italic>\n                    alters SARS\u2010CoV\u20102 vaccine\u2010induced immunity. Forty healthy volunteers were evaluated at five time points before and after receiving either the Pfizer\u2010BioNTech or Oxford\u2010AstraZeneca COVID\u201019 vaccines. Serum levels of anti\u2010\n                    <jats:italic>Anisakis<\/jats:italic>\n                    and anti\u2010SARS\u2010CoV\u20102 antibodies were quantified by ELISA, whereas T\u2010 and B\u2010cell subsets and apoptosis rates were analysed by flow cytometry. SARS\u2010CoV\u20102 vaccination induced significant changes in anti\u2010\n                    <jats:italic>Anisakis<\/jats:italic>\n                    antibody levels, particularly IgG and IgA, which increased after the second dose and persisted throughout follow\u2010up. Individuals seropositive for anti\u2010\n                    <jats:italic>Anisakis<\/jats:italic>\n                    antibodies exhibited higher post\u2010vaccination anti\u2010SARS\u2010CoV\u20102 IgG levels, and anti\u2010\n                    <jats:italic>Anisakis<\/jats:italic>\n                    IgA positivity correlated with stronger anti\u2010SARS\u2010CoV\u20102 IgA responses at specific time points. Positive associations were also observed between anti\u2010\n                    <jats:italic>Anisakis<\/jats:italic>\n                    antibody levels and circulating T\u2010 and B\u2010cell subsets. Prior sensitization to\n                    <jats:italic>Anisakis<\/jats:italic>\n                    antigens appears to influence both the magnitude and quality of the adaptive immune response elicited by SARS\u2010CoV\u20102 vaccination, affecting antibody profiles and lymphocyte subset dynamics. Conversely, COVID\u201019 vaccination can alter humoral reactivity to\n                    <jats:italic>Anisakis<\/jats:italic>\n                    antigens, indicating bidirectional immunomodulation between parasite exposure and vaccine\u2010induced immunity.\n                  <\/jats:p>","DOI":"10.1111\/pim.70101","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:55:12Z","timestamp":1789530912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Prior Exposure to\n                    <i>Anisakis simplex<\/i>\n                    Antigens on Immune Response During\n                    <scp>SARS<\/scp>\n                    \u2010\n                    <scp>CoV<\/scp>\n                    \u20102 Vaccination"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7948-9889","authenticated-orcid":false,"given":"Carmen","family":"Cu\u00e9llar","sequence":"first","affiliation":[{"name":"Microbiology and Parasitology Department Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rodero","sequence":"additional","affiliation":[{"name":"Microbiology and Parasitology Department Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0306-8399","authenticated-orcid":false,"given":"Juan","family":"Gonz\u00e1lez\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Microbiology and Parasitology Department Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Galindo\u2010Regal","sequence":"additional","affiliation":[{"name":"FISABIO Foundation  Valencia Spain"},{"name":"Laboratory of Molecular Biology and Research Department Arnau de Vilanova University Hospital, FISABIO Foundation  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"L\u00f3pez\u2010Chuli\u00e1","sequence":"additional","affiliation":[{"name":"FISABIO Foundation  Valencia Spain"},{"name":"Hematology Department Arnau de Vilanova Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Garc\u00eda\u2010Ballesteros","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology and Research Department Arnau de Vilanova University Hospital, FISABIO Foundation  Valencia Spain"},{"name":"Hematology Department Arnau de Vilanova Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Fern\u00e1ndez\u2010Murga","sequence":"additional","affiliation":[{"name":"Molecular Oncology Laboratory Arnau de Vilanova Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4515-8293","authenticated-orcid":false,"given":"Antonio","family":"Llombart\u2010Cussac","sequence":"additional","affiliation":[{"name":"Oncology Department Arnau de Vilanova Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Victoria","family":"Dom\u00ednguez\u2010M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Microbiology Department Arnau de Vilanova Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3790-3054","authenticated-orcid":false,"given":"Juan Carlos","family":"Andreu\u2010Ballester","sequence":"additional","affiliation":[{"name":"FISABIO Foundation  Valencia 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