{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T21:53:31Z","timestamp":1764194011152},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Coronary artery aneurysms are rare complications of autosomal dominant polycystic kidney disease (ADPKD), and their pathogenesis remains poorly understood. We report an autopsy case of a 64\u2010year\u2010old ADPKD patient with an asymptomatic, large (4\u2003cm in diameter) saccular aneurysm arising from the left circumflex (LCX) branch of the coronary artery with only mild atherosclerotic changes. Autopsy also revealed small, focal defects of media with or without microaneurysm formation in the LCX, mesenteric and renal arteries, and a fibromuscular dysplasia\u2010like lesion with microaneurysm in the common iliac artery. Since polycystin\u20101 and \u20102 are expressed in arterial smooth\u2010muscle cells, these findings imply that abnormal polycystin expression in ADPKD initially causes the focal medial defects, some of which might later progress to microaneurysms and then overt aneurysms. To the best of our knowledge, this is the first description of the pathologic findings of an ADPKD\u2010associated coronary aneurysm and its probable precursor lesions in arteries.<\/jats:p>","DOI":"10.1111\/pin.12007","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T02:38:47Z","timestamp":1351823927000},"page":"758-762","source":"Crossref","is-referenced-by-count":7,"title":["A large coronary aneurysm and its probable precursor lesions in a patient with autosomal dominant polycystic kidney disease: An implication for the process of aneurysmogenesis"],"prefix":"10.1111","volume":"62","author":[{"given":"Kentaro","family":"Ohara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokuhiro","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Karasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirobumi","family":"Tokuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Wakino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.13"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V95837"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00179997"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(94)90065-5"},{"key":"e_1_2_5_6_2","first-page":"21","article-title":"Polycystic kidney disease as a new risk factor for coronary events","volume":"4","author":"Magadle R","year":"2002","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.48.2570"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000124926.76836.df"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V84616"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1211"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000163278.68142.8a"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.08.045"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.1.183"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.79.934.474"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.149252"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg190"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12007","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T10:14:18Z","timestamp":1697278458000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/pin.12007"],"URL":"https:\/\/doi.org\/10.1111\/pin.12007","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}