{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T23:14:24Z","timestamp":1768778064928,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T00:00:00Z","timestamp":1361491200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Human T<\/jats:styled-content>\u2010cell leukemia virus type 1 (HTLV<\/jats:styled-content>\u20101) carriers are rarely subject to inflammatory disorders in multiple organs, other than the well\u2010known complication, adult T<\/jats:styled-content>\u2010cell leukemia\/lymphoma (ATLL<\/jats:styled-content>). HTLV<\/jats:styled-content>\u20101 associated bronchiolo\u2010alveolar disorder (HABA<\/jats:styled-content>) has been proposed as an immune mediated pulmonary reaction seen rarely in HTLV<\/jats:styled-content>\u20101 carriers. The reported clinico\u2010pathological patterns of HABA<\/jats:styled-content> are diffuse panbronchiolitis (DPB<\/jats:styled-content>) and lymphoid interstitial pneumonia (LIP<\/jats:styled-content>).<\/jats:p>We here report three cases of HTLV<\/jats:styled-content>\u20101 carriers showing miliary micro\u2010nodules throughout both lungs. Microscopic examination in the video assisted thoracic surgery biopsies demonstrated that all cases had multiple discrete micro\u2010nodules which consisted of marked lymphoid infiltration, granulomas, eosinophils and a few foci of necrosis inside the granuloma. No findings indicating ATLL<\/jats:styled-content>, other neoplastic conditions, infection or interstitial pneumonia, including DPB<\/jats:styled-content> and LIP<\/jats:styled-content>, were present following panels of special staining and immunohistochemical examinations. Two patients improved without treatment within one month, with no evidence of recurrence after 7 years. One patient showed slow deterioration of lung reticular shadows in spite of a low dose corticosteroid therapy (prednisolone 10\u2009mg\/day). We believe these cases may be a newly recognized variant of HABA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pin.12030","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T08:38:58Z","timestamp":1361522338000},"page":"108-112","source":"Crossref","is-referenced-by-count":7,"title":["Lung miliary micro\u2010nodules in human T<\/scp>\u2010cell leukemia virus type I<\/scp> carriers"],"prefix":"10.1111","volume":"63","author":[{"given":"Junya","family":"Fukuoka","sequence":"first","affiliation":[{"name":"Laboratory of Pathology Toyama University Hospital Toyama Japan"},{"name":"Department of Surgical Pathology Toyama University Hospital Toyama Japan"},{"name":"Department of Pathology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology Toyama University Hospital Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Ichikado","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Saiseikai Kumamoto Hospital Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology Toyama University Hospital Toyama Japan"},{"name":"Department of Pathology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Ichiyasu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotsugu","family":"Kohrogi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Ishizawa","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology Toyama University Hospital Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritaka","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Saiseikai Kumamoto Hospital Kumamoto 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