{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:25:29Z","timestamp":1763036729915},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T00:00:00Z","timestamp":1361491200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Sclerosing mucoepidermoid carcinoma with eosinophilia (<jats:styled-content style=\"fixed-case\">SMCE<\/jats:styled-content>) of the salivary gland is a rare variant of mucoepidermoid carcinoma. We report a case of <jats:styled-content style=\"fixed-case\">SMCE<\/jats:styled-content> in the right submandibular gland of a 79\u2010year\u2010old man. Fine needle aspiration cytology revealed cohesive clusters of atypical squamous epithelial cells admixed with cells containing intracytoplasmic mucin and eosinophils. Histologically, the tumor was composed of epithelial nests with keratinizing cells occasionally present at the center, as well as peripherally located atypical basaloid cells, and some mucin\u2010containing cells embedded in a fibrosclerotic stroma, which were accompanied by a prominent lymphoplasmacytic and eosinophilic infiltrate. Inflammatory infiltrate and stromal fibrosclerosis also were seen in the non\u2010neoplastic salivary gland tissue adjacent to the tumor. Immunohistochemically, many plasma cells were <jats:styled-content style=\"fixed-case\">IgG4<\/jats:styled-content>\u2010positive. The postoperative serum <jats:styled-content style=\"fixed-case\">IgG4<\/jats:styled-content> level was elevated. Our reverse transcription\u2010polymerase chain reaction using formalin\u2010fixed, paraffin\u2010embedded tumor tissue failed to detect any fusion\u2010gene transcripts which are specifically identified in ordinary mucoepidermoid carcinoma. The findings of the present case suggest that this rare type of salivary gland carcinoma may be associated with a chronic inflammatory condition such as <jats:styled-content style=\"fixed-case\">IgG4<\/jats:styled-content>\u2010related sclerosing disease. Only 23 cases of sclerosing mucoepidermoid carcinoma with or without eosinophilic infiltratie have been reported to date in such an anatomical location.<\/jats:p>","DOI":"10.1111\/pin.12035","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T08:39:09Z","timestamp":1361522349000},"page":"125-131","source":"Crossref","is-referenced-by-count":36,"title":["Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary gland: Case report and review of the literature"],"prefix":"10.1111","volume":"63","author":[{"given":"Takashi","family":"Tasaki","sequence":"first","affiliation":[{"name":"Department of Pathology and Cell Biology University of Occupational and Environmental Health  Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuji","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oncology University of Occupational and Environmental Health  Kitakyushu 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