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The aim of the present study is to characterize immune granuloma cells in 33 patients with granulomatous inflammation focusing on the expression of CD205<\/jats:styled-content> (DEC205<\/jats:styled-content>), a cell surface marker of antigen presenting cells, and their spatial relationship to T<\/jats:styled-content> cells. CD205<\/jats:styled-content> was frequently expressed by immune granuloma cells, in contrast to foreign body granuloma cells that lacked CD205<\/jats:styled-content> expression. T<\/jats:styled-content> cells were not only distributed in a lymphocyte collar around the granuloma, but also present among the granuloma cells (termed \u2018intra\u2010granuloma T<\/jats:styled-content> cells\u2019). Intra\u2010granuloma T<\/jats:styled-content> cells stained positive for K<\/jats:styled-content>i\u201067 (median positivity = 9.4%) by double immunostaining for CD3<\/jats:styled-content> and K<\/jats:styled-content>i\u201067. This indicated the presence of proliferative stimuli within the granuloma that could activate the intra\u2010granuloma T<\/jats:styled-content> cells. The labeling index of K<\/jats:styled-content>i\u201067 in intra\u2010granuloma T<\/jats:styled-content> cells was significantly higher than that of T<\/jats:styled-content> cells in the lymphocyte collar (P<\/jats:italic> < 0.0001) or T<\/jats:styled-content> cells in the T<\/jats:styled-content> cell zone (paracortex) of chronic tonsillitis or reactive lymphadenitis (P<\/jats:italic> = 0.002). These data indicate a close similarity between immune granulomas and antigen presenting cells.<\/jats:p>","DOI":"10.1111\/pin.12036","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T08:39:12Z","timestamp":1361522352000},"page":"85-93","source":"Crossref","is-referenced-by-count":13,"title":["Granuloma cells in chronic inflammation express CD205<\/scp> (DEC205<\/scp>) antigen and harbor proliferating T<\/scp> lymphocytes: Similarity to antigen\u2010presenting cells"],"prefix":"10.1111","volume":"63","author":[{"given":"Haruo","family":"Ohtani","sequence":"first","affiliation":[{"name":"Department of Pathology Mito Medical Center National Hospital Organization Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"73","volume-title":"Robbins and Contran Pathologic Basis of Disease","author":"Kumar 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